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. 1984 Apr;44(1):188–193. doi: 10.1128/iai.44.1.188-193.1984

Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.

K D Bremm, H J Brom, J E Alouf, W König, B Spur, A Crea, W Peters
PMCID: PMC263491  PMID: 6323315

Abstract

We investigated the effect of alveolysin on human granulocytes. Alveolysin is an exoprotein produced by Bacillus alvei and belongs to the group of sulfhydryl-activated cytolysins. Other members of this group are streptolysin O and theta-toxin from Clostridium perfringens. It is demonstrated that alveolysin leads to leukotriene generation from human granulocytes, which exert chemotactic (leukotriene B4) and slow-reacting substance (leukotriene C4, D4, and E4) activity under sublytic concentrations.

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Selected References

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