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. 1993 Apr;31(4):911–916. doi: 10.1128/jcm.31.4.911-916.1993

Identification of group-common linear epitopes in structural and nonstructural proteins of enteroviruses by using synthetic peptides.

J Cello 1, A Samuelson 1, P Stålhandske 1, B Svennerholm 1, S Jeansson 1, M Forsgren 1
PMCID: PMC263586  PMID: 7681848

Abstract

Synthetic peptides were employed in enzyme-linked immunosorbent assays to identify group-common linear epitopes in the structural and nonstructural proteins of enteroviruses. Nine linear epitopes were recognized by using sera from patients with heterotypic immunoglobulin G antibody responses to enterovirus infections. The most-reactive peptides were derived from conserved regions of the amino-terminal part of VP1, whereas peptides representing sequences from other conserved regions of VP1, as well as VP2, VP3, and VP4, and from a nonstructural region showed no or poor reactivity. These findings may be useful in the development of serological tests for the diagnosis of infections caused by a broad range of enteroviruses.

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Selected References

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