Table 3.

Single Nucleotide Polymorphisms (SNPs) used in this study and the association analysis (significant results are in bold). The results for the family-based association analysis of the North European (NE) and Caribbean Hispanic (CH) FAD families, and for the two-point analysis of the NE case-control dataset. (A) Minor Allele Frequency. (B) SNPs genotyped by Li et al study (2004). (C) SNPs genotyped by Lin et al. study (2006). (D) rs3741916 is now known as rs1136666. (E) Not Informative. SNP information was obtained from the NCBI site (www.ncbi.nlm.nih.gov/SNP, NCBI build 35; www.genome.ucsc.edu, Assembly May 2004).

Order	Gene Name	SNP Function	RS #	Chrom. Position	Distance (kb)	NE Case Control Dataset					NE FAD	CH FAD
						p-value
						Genotype	Allele	MAFa Cases	MAF Controls	Associated Allele	p-value FBAT	p-value FBAT	Associated Allele
1	TAPBPL	V146M	2532501	6,433,014		0.047	0.121	0.40	0.34	A	0.3570	0.1377	A
2	TAPBPL	A165T	2532500	6,433,071	0.06	0.006	0.043	0.43	0.34	T	0.3670	0.3293	T
3	PKP2P1	5'UTR	2008134B,C	6,458,706	25.64	0.975	0.881	0.29	0.30		0.9300	0.4169
4	NCAPD2	intronic	2072373B	6,502,149	43.44	0.109	0.289	0.12	0.14		0.4560	0.6144
5	NCAPD2	intronic	7311174B,C	6,505,828	3.68	0.561	0.784	0.29	0.28		0.3850	0.4629
6	NCAPD2	R1100R	2072374B,C	6,508,106	2.28	0.686	0.780	0.29	0.28		0.3960	0.4298
7	NCAPD2	N1161N	740850	6,508,377	0.27	0.039	0.046	0.40	0.33	A	0.2950	0.0097	A
8	GAPDH	5'UTR	3741916B,C,D	6,514,252	5.88	0.054	0.027	0.14	0.21	C	0.2710	0.1982	C
9	GAPDH	intron	3741918 C	6,514,517	0.27	0.032	0.030	0.14	0.17	A	0.1030	0.6071	A
10	GAPDH	intron	1060620 C	6,514,983	0.47	0.432	0.795	0.17	0.18	T	0.5050	0.0418	T
11	GAPDH	intron	1060619 C	6,515,042	0.06	0.180	0.254	0.19	0.19		0.1030	0.9802
12	HOM-TES-103	intron	740852	6,520,587	5.55	0.180	0.970	0.08	0.07		0.1950	0.6076
13	CHD4	D139E	1639122	6,581,408	60.82	0.065	0.018	0.24	0.33	A	0.6870	0.2248	A
14	GPR92	A153A	3741924	6,600,217	18.81	0.025	0.004	0.04	0.07	T	N/IE	N/IE