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. 1984 Jun;44(3):633–636. doi: 10.1128/iai.44.3.633-636.1984

Isotype of protective anti-Salmonella antibodies in experimental mouse salmonellosis.

H Saxén, O Mäkelä, S B Svenson
PMCID: PMC263652  PMID: 6202639

Abstract

Mice and a rabbit were immunized with heat-killed Salmonella typhimurium bacteria or with an O-4,12 antigen-specific octasaccharide-protein conjugate. Immunoglobulin isotypes of the antisera were tested for their capacity to protect mice against experimental salmonellosis. Antibodies of immunoglobulin M + A isotypes were more protective than the immunoglobulin G antibodies in each of the two pools of mouse sera. The same protective pattern was also seen with a rabbit antiserum elicited by the artificial octasaccharide-protein conjugate, i.e., with antibodies with the exclusive specificity for the O-4,12 antigen determinants of S. typhimurium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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