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. 1994 May;32(5):1366–1368. doi: 10.1128/jcm.32.5.1366-1368.1994

Selective isolation of poliovirus in recombinant murine cell line expressing the human poliovirus receptor gene.

T Hovi 1, M Stenvik 1
PMCID: PMC263705  PMID: 8051271

Abstract

Sixty-eight laboratory strains representing 49 enterovirus, 10 adenovirus, and 3 reovirus serotypes were inoculated in a recombinant murine cell line expressing the human poliovirus receptor gene (L alpha cells). Only polioviruses caused cytopathic effect over a 10-day period. Likewise, only polioviruses were isolated, by use of L alpha cells, from 168 fecal specimens from children from developing countries. These results suggest that the recombinant L alpha cells can be used for selective isolation of poliovirus from clinical specimens.

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Selected References

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