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. 1994 Sep;32(9):2266–2269. doi: 10.1128/jcm.32.9.2266-2269.1994

Comparison of plasma PCR and bronchoalveolar lavage fluid culture for detection of cytomegalovirus infection in adult bone marrow transplant recipients.

M M Aspin 1, G M Gallez-Hawkins 1, T D Giugni 1, B Tegtmeier 1, D J Lang 1, G M Schmidt 1, S J Forman 1, J A Zaia 1
PMCID: PMC263979  PMID: 7814556

Abstract

Plasma PCR for human cytomegalovirus (CMV) DNA was compared with bronchoalveolar lavage (BAL) fluid culture as an indicator for disseminated CMV infection. Thirteen (32.5%) of 40 consecutive bone marrow transplant (BMT) recipients were BAL fluid culture positive for CMV on day 35 post-BMT, and 9 (69%) of the 13 had positive plasma PCRs between days 28 and 49. Of the 27 with negative BAL fluid cultures, 2 (7%) had positive plasma PCRs (P < 0.001). Plasma CMV DNA in BMT recipients is a useful clinical marker for serious infection.

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Selected References

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