Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1994 Sep;32(9):2307–2308. doi: 10.1128/jcm.32.9.2307-2308.1994

Effect of potential interference factors on performance of enzyme immunoassay and latex agglutination assay for cryptococcal antigen.

H D Engler 1, Y R Shea 1
PMCID: PMC263991  PMID: 7814565

Abstract

The PREMIER Cryptococcal Antigen Enzyme Immunoassay (Meridian Diagnostics) did not give discrepant results with rheumatoid factor, syneresis fluid, or serum macroglobulins from systemic lupus erythematosis patients. The Cryptococcal Antigen Latex Agglutination System (Meridian Diagnostics) did cross-react with syneresis fluid but not with the other serum factors tested.

Full text

PDF
2307

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett J. E., Bailey J. W. Control for rheumatoid factor in the latex test for cryptococcosis. Am J Clin Pathol. 1971 Sep;56(3):360–365. doi: 10.1093/ajcp/56.3.360. [DOI] [PubMed] [Google Scholar]
  2. Boom W. H., Piper D. J., Ruoff K. L., Ferraro M. J. New cause for false-positive results with the cryptococcal antigen test by latex agglutination. J Clin Microbiol. 1985 Nov;22(5):856–857. doi: 10.1128/jcm.22.5.856-857.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eng R. H., Person A. Serum cryptococcal antigen determination in the presence of rheumatoid factor. J Clin Microbiol. 1981 Dec;14(6):700–702. doi: 10.1128/jcm.14.6.700-702.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gade W., Hinnefeld S. W., Babcock L. S., Gilligan P., Kelly W., Wait K., Greer D., Pinilla M., Kaplan R. L. Comparison of the PREMIER cryptococcal antigen enzyme immunoassay and the latex agglutination assay for detection of cryptococcal antigens. J Clin Microbiol. 1991 Aug;29(8):1616–1619. doi: 10.1128/jcm.29.8.1616-1619.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gray L. D., Roberts G. D. Experience with the use of pronase to eliminate interference factors in the latex agglutination test for cryptococcal antigen. J Clin Microbiol. 1988 Nov;26(11):2450–2451. doi: 10.1128/jcm.26.11.2450-2451.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hamilton J. R., Noble A., Denning D. W., Stevens D. A. Performance of cryptococcus antigen latex agglutination kits on serum and cerebrospinal fluid specimens of AIDS patients before and after pronase treatment. J Clin Microbiol. 1991 Feb;29(2):333–339. doi: 10.1128/jcm.29.2.333-339.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hay R. J., Mackenzie D. W. False positive latex tests for cryptococcal antigen in cerebrospinal fluid. J Clin Pathol. 1982 Feb;35(2):244–245. doi: 10.1136/jcp.35.2.244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McManus E. J., Jones J. M. Detection of a Trichosporon beigelii antigen cross-reactive with Cryptococcus neoformans capsular polysaccharide in serum from a patient with disseminated Trichosporon infection. J Clin Microbiol. 1985 May;21(5):681–685. doi: 10.1128/jcm.21.5.681-685.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Perfect J. R. Cryptococcosis. Infect Dis Clin North Am. 1989 Mar;3(1):77–102. [PubMed] [Google Scholar]
  10. Stamm A. M., Polt S. S. False-negative cryptococcal antigen test. JAMA. 1980 Sep 19;244(12):1359–1359. [PubMed] [Google Scholar]
  11. Stockman L., Roberts G. D. Corrected version specificity of the latex test for cryptococcal antigen: a rapid, simple method for eliminating interference factors. J Clin Microbiol. 1983 May;17(5):945–947. doi: 10.1128/jcm.17.5.945-947.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES