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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1994 Sep;32(9):2335–2337. doi: 10.1128/jcm.32.9.2335-2337.1994

Hafnia alvei in stool specimens from patients with diarrhea and healthy controls.

J Ridell 1, A Siitonen 1, L Paulin 1, L Mattila 1, H Korkeala 1, M J Albert 1
PMCID: PMC264000  PMID: 7814573

Abstract

We found an epidemiological association of Hafnia alvei with diarrhea, because the organism was isolated from 12 of 77 (16%) adult Finnish tourists to Morocco who developed diarrhea and from 0 of 321 tourists without diarrhea (P < 0.001). From another group of 112 adult Finnish diarrheal patients, only 2 (2%) yielded H. alvei. In contrast to some Bangladeshi strains of H. alvei, the Finnish strains were negative for the attachment-effacement lesion by an in vitro fluorescent acting staining test and also did not show homology to the Escherichia coli attachment-effacement gene (eaeA) by PCR. These results suggest that a mechanism or mechanisms other than the attachment-effacement lesion may also be involved in the association of H. alvei with diarrhea.

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Selected References

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  1. Albert M. J., Alam K., Islam M., Montanaro J., Rahaman A. S., Haider K., Hossain M. A., Kibriya A. K., Tzipori S. Hafnia alvei, a probable cause of diarrhea in humans. Infect Immun. 1991 Apr;59(4):1507–1513. doi: 10.1128/iai.59.4.1507-1513.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Albert M. J., Faruque S. M., Ansaruzzaman M., Islam M. M., Haider K., Alam K., Kabir I., Robins-Browne R. Sharing of virulence-associated properties at the phenotypic and genetic levels between enteropathogenic Escherichia coli and Hafnia alvei. J Med Microbiol. 1992 Nov;37(5):310–314. doi: 10.1099/00222615-37-5-310. [DOI] [PubMed] [Google Scholar]
  3. Fanghänel S., Reissbrodt R., Giesecke H. L-prolineaminopeptidase activity as a tool for identification and differentiation of Serratia marcescens, Serratia liquefaciens and Hafnia alvei strains. Zentralbl Bakteriol. 1991 Apr;275(1):11–15. doi: 10.1016/s0934-8840(11)80763-2. [DOI] [PubMed] [Google Scholar]
  4. Jerse A. E., Yu J., Tall B. D., Kaper J. B. A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7839–7843. doi: 10.1073/pnas.87.20.7839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mattila L., Siitonen A., Kyrönseppä H., Simula I., Oksanen P., Stenvik M., Salo P., Peltola H. Seasonal variation in etiology of travelers' diarrhea. Finnish-Moroccan Study Group. J Infect Dis. 1992 Feb;165(2):385–388. doi: 10.1093/infdis/165.2.385. [DOI] [PubMed] [Google Scholar]
  6. Ratnam S. Etiologic role of Hafnia alvei in human diarrheal illness. Infect Immun. 1991 Dec;59(12):4744–4745. doi: 10.1128/iai.59.12.4744-4745.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Reina J., Hervas J., Borrell N. Acute gastroenteritis caused by Hafnia alvei in children. Clin Infect Dis. 1993 Mar;16(3):443–443. doi: 10.1093/clind/16.3.443. [DOI] [PubMed] [Google Scholar]
  8. Schauer D. B., Falkow S. The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia. Infect Immun. 1993 Nov;61(11):4654–4661. doi: 10.1128/iai.61.11.4654-4661.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Steigerwalt A. G., Fanning G. R., Fife-Asbury M. A., Brenner D. J. DNA relatedness among species of Enterobacter and Serratia. Can J Microbiol. 1976 Feb;22(2):121–137. doi: 10.1139/m76-018. [DOI] [PubMed] [Google Scholar]
  10. Westblom T. U., Milligan T. W. Acute bacterial gastroenteritis caused by Hafnia alvei. Clin Infect Dis. 1992 Jun;14(6):1271–1272. doi: 10.1093/clinids/14.6.1271. [DOI] [PubMed] [Google Scholar]

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