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. 1998 Apr-Jun;4(2):229–237. doi: 10.3201/eid0402.980210

Haemophilus influenzae invasive disease in the United States, 1994-1995: near disappearance of a vaccine-preventable childhood disease.

K M Bisgard 1, A Kao 1, J Leake 1, P M Strebel 1, B A Perkins 1, M Wharton 1
PMCID: PMC2640137  PMID: 9621193

Abstract

We analyzed national Haemophilus influenzae (Hi) surveillance data from 1994 and 1995 to describe the epidemiology of Hi invasive disease among persons of all ages. Serotype data were available for 376 (56%) of 669 reported Hi cases among children aged 4 years or younger; 184 (49%) were H. influenzae type b (Hib). Among children aged 4 or younger, incidence (per 100,000) of all Hi invasive disease was 1.8 in 1994 and 1.6 (p < 0.05) in 1995. Children aged 5 months or younger had the highest average annual incidence rate of Hib invasive disease (2.2 per 100,000); children aged 6 to 11 months had the next highest rate (1.2 per 100,000)(p < 0.05). Of 181 children with Hib invasive disease whose age in months was known, 85 (47%) were too young (aged 5 months or younger) to have completed a primary series with an Hib-containing vaccine. Of the 83 children with known vaccination status who were eligible to receive a primary series (aged 6 months or older), 52 (63%) were undervaccinated, and the remaining 31 (37%) had completed a primary series in which vaccine failed. Among persons aged 5 years or older with Hi invasive disease, the lowest average annual incidence was among those 20 to 39 years of age (0.15 per 100,000), and the highest was among those aged 80 years or older (2.26 per 100,000). Among persons aged 5 years or older, serotype data were available for 1,372 (71%) of the 1,940 Hi invasive disease cases; 159 (28%) of the 568 Hi cases with known serotype were due to Hib.

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Selected References

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  1. Abramson J. S., O'Shea T. M., Ratledge D. L., Lawless M. R., Givner L. B. Development of a vaccine tracking system to improve the rate of age-appropriate primary immunization in children of lower socioeconomic status. J Pediatr. 1995 Apr;126(4):583–586. doi: 10.1016/s0022-3476(95)70354-3. [DOI] [PubMed] [Google Scholar]
  2. Adams W. G., Deaver K. A., Cochi S. L., Plikaytis B. D., Zell E. R., Broome C. V., Wenger J. D. Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era. JAMA. 1993 Jan 13;269(2):221–226. [PubMed] [Google Scholar]
  3. Barbour M. L. Conjugate vaccines and the carriage of Haemophilus influenzae type b. Emerg Infect Dis. 1996 Jul-Sep;2(3):176–182. doi: 10.3201/eid0203.960303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Campbell J. R., Szilagyi P. G., Rodewald L. E., Doane C., Roghmann K. J. Patient-specific reminder letters and pediatric well-child-care show rates. Clin Pediatr (Phila) 1994 May;33(5):268–272. doi: 10.1177/000992289403300503. [DOI] [PubMed] [Google Scholar]
  5. Centers for Disease Control and Prevention (CDC) National, state, and urban area vaccination coverage levels among children aged 19-35 months--United States, January-December 1995. MMWR Morb Mortal Wkly Rep. 1997 Feb 28;46(8):176–182. [PubMed] [Google Scholar]
  6. Centers for Disease Control and Prevention (CDC) Progress toward elimination of Haemophilus influenzae type b disease among infants and children--United States, 1987-1995. MMWR Morb Mortal Wkly Rep. 1996 Oct 25;45(42):901–906. [PubMed] [Google Scholar]
  7. Centers for Disease Control and Prevention (CDC) Recommendations of the Advisory Committee on Immunization Practices: programmatic strategies to increase vaccination coverage by age 2 years--linkage of vaccination and WIC services. MMWR Morb Mortal Wkly Rep. 1996 Mar 15;45(10):217–218. [PubMed] [Google Scholar]
  8. Centers for Disease Control and Prevention (CDC) Recommendations of the Advisory Committee on Immunization Practices: programmatic strategies to increase vaccination rates--assessment and feedback of provider-based vaccination coverage information. MMWR Morb Mortal Wkly Rep. 1996 Mar 15;45(10):219–220. [PubMed] [Google Scholar]
  9. Centers for Disease Control and Prevention (CDC) Reported vaccine-preventable diseases--United States, 1993, and the childhood immunization initiative. MMWR Morb Mortal Wkly Rep. 1994 Feb 4;43(4):57–60. [PubMed] [Google Scholar]
  10. Cochi S. L., Broome C. V., Hightower A. W. Immunization of US children with Hemophilus influenzae type b polysaccharide vaccine. A cost-effectiveness model of strategy assessment. JAMA. 1985 Jan 25;253(4):521–529. [PubMed] [Google Scholar]
  11. Cochi S. L., Fleming D. W., Hightower A. W., Limpakarnjanarat K., Facklam R. R., Smith J. D., Sikes R. K., Broome C. V. Primary invasive Haemophilus influenzae type b disease: a population-based assessment of risk factors. J Pediatr. 1986 Jun;108(6):887–896. doi: 10.1016/s0022-3476(86)80922-2. [DOI] [PubMed] [Google Scholar]
  12. Dini E. F., Linkins R. W., Chaney M. Effectiveness of computer-generated telephone messages in increasing clinic visits. Arch Pediatr Adolesc Med. 1995 Aug;149(8):902–905. doi: 10.1001/archpedi.1995.02170210076013. [DOI] [PubMed] [Google Scholar]
  13. Farley M. M., Stephens D. S., Brachman P. S., Jr, Harvey R. C., Smith J. D., Wenger J. D. Invasive Haemophilus influenzae disease in adults. A prospective, population-based surveillance. CDC Meningitis Surveillance Group. Ann Intern Med. 1992 May 15;116(10):806–812. doi: 10.7326/0003-4819-116-10-806. [DOI] [PubMed] [Google Scholar]
  14. Granoff D. M., Basden M. Haemophilus influenzae infections in Fresno County, California: a prospective study of the effects of age, race, and contact with a case on incidence of disease. J Infect Dis. 1980 Jan;141(1):40–46. doi: 10.1093/infdis/141.1.40. [DOI] [PubMed] [Google Scholar]
  15. Kostman J. R., Sherry B. L., Fligner C. L., Egaas S., Sheeran P., Baken L., Bauwens J. E., Clausen C., Sherer D. M., Plorde J. J. Invasive Haemophilus influenzae infections in older children and adults in Seattle. Clin Infect Dis. 1993 Sep;17(3):389–396. doi: 10.1093/clinids/17.3.389. [DOI] [PubMed] [Google Scholar]
  16. Mohle-Boetani J. C., Ajello G., Breneman E., Deaver K. A., Harvey C., Plikaytis B. D., Farley M. M., Stephens D. S., Wenger J. D. Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines. Pediatr Infect Dis J. 1993 Jul;12(7):589–593. doi: 10.1097/00006454-199307000-00009. [DOI] [PubMed] [Google Scholar]
  17. Murphy T. V., Osterholm M. T., Pierson L. M., White K. E., Breedlove J. A., Seibert G. B., Kuritsky J. N., Granoff D. M. Prospective surveillance of Haemophilus influenzae type b disease in Dallas County, Texas, and in Minnesota. Pediatrics. 1987 Feb;79(2):173–180. [PubMed] [Google Scholar]
  18. Standaert S. M., Lefkowitz L. B., Jr, Horan J. M., Hutcheson R. H., Schaffner W. The reporting of communicable diseases: a controlled study of Neisseria meningitidis and Haemophilus influenzae infections. Clin Infect Dis. 1995 Jan;20(1):30–36. doi: 10.1093/clinids/20.1.30. [DOI] [PubMed] [Google Scholar]
  19. Steinhart R., Reingold A. L., Taylor F., Anderson G., Wenger J. D. Invasive Haemophilus influenzae infections in men with HIV infection. JAMA. 1992 Dec 16;268(23):3350–3352. [PubMed] [Google Scholar]
  20. Strebel P. M., Sutter R. W., Cochi S. L., Biellik R. J., Brink E. W., Kew O. M., Pallansch M. A., Orenstein W. A., Hinman A. R. Epidemiology of poliomyelitis in the United States one decade after the last reported case of indigenous wild virus-associated disease. Clin Infect Dis. 1992 Feb;14(2):568–579. doi: 10.1093/clinids/14.2.568. [DOI] [PubMed] [Google Scholar]
  21. Takala A. K., Eskola J., van Alphen L. Spectrum of invasive Haemophilus influenzae type b disease in adults. Arch Intern Med. 1990 Dec;150(12):2573–2576. [PubMed] [Google Scholar]
  22. Ward J. I., Lum M. K., Hall D. B., Silimperi D. R., Bender T. R. Invasive Haemophilus influenzae type b disease in Alaska: background epidemiology for a vaccine efficacy trial. J Infect Dis. 1986 Jan;153(1):17–26. doi: 10.1093/infdis/153.1.17. [DOI] [PubMed] [Google Scholar]

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