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. 1998 Oct-Dec;4(4):615–617. doi: 10.3201/eid0404.980411

Mutators and long-term molecular evolution of pathogenic Escherichia coli O157:H7.

T S Whittam 1, S D Reid 1, R K Selander 1
PMCID: PMC2640239  PMID: 9866737

Abstract

It has been proposed that an increased mutation rate (indicated by the frequency of hypermutable isolates) has facilitated the emergence of Escherichia coli O157:H7. Analysis of the divergence of 12 genes shows no evidence that the pathogen has undergone an unusually high rate of mutation and molecular evolution.

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Selected References

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