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. 1999 May-Jun;5(3):367–378. doi: 10.3201/eid0503.990307

Emergence of a unique group of necrotizing mycobacterial diseases.

K M Dobos 1, F D Quinn 1, D A Ashford 1, C R Horsburgh 1, C H King 1
PMCID: PMC2640780  PMID: 10341173

Abstract

Although most diseases due to pathogenic mycobacteria are caused by Mycobacterium tuberculosis, several other mycobacterial diseases-caused by M. ulcerans (Buruli ulcer), M. marinum, and M. haemophilum-have begun to emerge. We review the emergence of diseases caused by these three pathogens in the United States and around the world in the last decade. We examine the pathophysiologic similarities of the diseases (all three cause necrotizing skin lesions) and common reservoirs of infection (stagnant or slow-flowing water). Examination of the histologic and pathogenic characteristics of these mycobacteria suggests differences in the modes of transmission and pathogenesis, though no singular mechanism for either characteristic has been definitively described for any of these mycobacteria.

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Selected References

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  1. Abbott M. R., Smith D. D. The pathogenic effects of Mycobacterium haemophilum in immunosuppressed albino mice. J Med Microbiol. 1980 Nov;13(4):535–540. doi: 10.1099/00222615-13-4-535. [DOI] [PubMed] [Google Scholar]
  2. Allen S. Buruli ulcer and HIV infection. Int J Dermatol. 1992 Oct;31(10):744–745. doi: 10.1111/j.1365-4362.1992.tb01390.x. [DOI] [PubMed] [Google Scholar]
  3. Bean N. H., Martin S. M., Bradford H., Jr PHLIS: an electronic system for reporting public health data from remote sites. Am J Public Health. 1992 Sep;82(9):1273–1276. doi: 10.2105/ajph.82.9.1273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CLARK H. F., SHEPARD C. C. EFFECT OF ENVIRONMENTAL TEMPERATURES ON INFECTION WITH MYCOBACTERIUM MARINUM (BALNEI) OF MICE AND A NUMBER OF POIKILOTHERMIC SPECIES. J Bacteriol. 1963 Nov;86:1057–1069. doi: 10.1128/jb.86.5.1057-1069.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Collins C. H., Grange J. M., Noble W. C., Yates M. D. Mycobacterium marinum infections in man. J Hyg (Lond) 1985 Apr;94(2):135–149. doi: 10.1017/s0022172400061349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Collins C. H., Grange J. M., Yates M. D. Mycobacteria in water. J Appl Bacteriol. 1984 Oct;57(2):193–211. doi: 10.1111/j.1365-2672.1984.tb01384.x. [DOI] [PubMed] [Google Scholar]
  7. DODGE O. G., LUNN H. F. Buruli ulcer: a mycobacterial skin ulcer in a Uganda child. J Trop Med Hyg. 1962 Jun;65:139–142. [PubMed] [Google Scholar]
  8. Dawson D. J., Jennis F. Mycobacteria with a growth requirement for ferric ammonium citrate, identified as Mycobacterium haemophilum. J Clin Microbiol. 1980 Feb;11(2):190–192. doi: 10.1128/jcm.11.2.190-192.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dawson J. F., Allen G. E. Ulcer due to Mycobacterium ulcerans in Northern Ireland. Clin Exp Dermatol. 1985 Nov;10(6):572–576. doi: 10.1111/j.1365-2230.1985.tb00625.x. [DOI] [PubMed] [Google Scholar]
  10. Delaporte E., Savage C., Alfandari S., Piette F., Leclerc H., Bergoend H. Ulcère de Buruli chez une malade zaïroise infectée par le virus de l'immunodéficience humaine. Ann Dermatol Venereol. 1994;121(8):557–560. [PubMed] [Google Scholar]
  11. Feldman R. A., Hershfield E. Mycobacterial skin infection by an unidentified species. A report of 29 patients. Ann Intern Med. 1974 Apr;80(4):445–452. doi: 10.7326/0003-4819-80-4-445. [DOI] [PubMed] [Google Scholar]
  12. George K. M., Barker L. P., Welty D. M., Small P. L. Partial purification and characterization of biological effects of a lipid toxin produced by Mycobacterium ulcerans. Infect Immun. 1998 Feb;66(2):587–593. doi: 10.1128/iai.66.2.587-593.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gluckman S. J. Mycobacterium marinum. Clin Dermatol. 1995 May-Jun;13(3):273–276. doi: 10.1016/0738-081x(95)00023-9. [DOI] [PubMed] [Google Scholar]
  14. Gouby A., Branger B., Oules R., Ramuz M. Two cases of Mycobacterium haemophilum infection in a renal-dialysis unit. J Med Microbiol. 1988 Apr;25(4):299–300. doi: 10.1099/00222615-25-4-299. [DOI] [PubMed] [Google Scholar]
  15. Hockmeyer W. T., Krieg R. E., Reich M., Johnson R. D. Further characterization of Mycobacterium ulcerans toxin. Infect Immun. 1978 Jul;21(1):124–128. doi: 10.1128/iai.21.1.124-128.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Horsburgh C. R., Jr Epidemiology of disease caused by nontuberculous mycobacteria. Semin Respir Infect. 1996 Dec;11(4):244–251. [PubMed] [Google Scholar]
  17. Kikuchi K., Bernard E. M., Kiehn T. E., Armstrong D., Riley L. W. Restriction fragment length polymorphism analysis of clinical isolates of Mycobacterium haemophilum. J Clin Microbiol. 1994 Jul;32(7):1763–1767. doi: 10.1128/jcm.32.7.1763-1767.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kozin S. H., Bishop A. T. Atypical Mycobacterium infections of the upper extremity. J Hand Surg Am. 1994 May;19(3):480–487. doi: 10.1016/0363-5023(94)90067-1. [DOI] [PubMed] [Google Scholar]
  19. MacCALLUM P., TOLHURST J. C. A new mycobacterial infection in man. J Pathol Bacteriol. 1948 Jan;60(1):93–122. [PubMed] [Google Scholar]
  20. McOrist S., Jerrett I. V., Anderson M., Hayman J. Cutaneous and respiratory tract infection with Mycobacterium ulcerans in two koalas (Phascolarctos cinereus). J Wildl Dis. 1985 Apr;21(2):171–173. doi: 10.7589/0090-3558-21.2.171. [DOI] [PubMed] [Google Scholar]
  21. Meyers W. M., Tignokpa N., Priuli G. B., Portaels F. Mycobacterium ulcerans infection (Buruli ulcer): first reported patients in Togo. Br J Dermatol. 1996 Jun;134(6):1116–1121. [PubMed] [Google Scholar]
  22. O'Brien R. J., Geiter L. J., Snider D. E., Jr The epidemiology of nontuberculous mycobacterial diseases in the United States. Results from a national survey. Am Rev Respir Dis. 1987 May;135(5):1007–1014. doi: 10.1164/arrd.1987.135.5.1007. [DOI] [PubMed] [Google Scholar]
  23. Parent L. J., Salam M. M., Appelbaum P. C., Dossett J. H. Disseminated Mycobacterium marinum infection and bacteremia in a child with severe combined immunodeficiency. Clin Infect Dis. 1995 Nov;21(5):1325–1327. doi: 10.1093/clinids/21.5.1325. [DOI] [PubMed] [Google Scholar]
  24. Portaels F., Dawson D. J., Larsson L., Rigouts L. Biochemical properties and fatty acid composition of Mycobacterium haemophilum: study of 16 isolates from Australian patients. J Clin Microbiol. 1993 Jan;31(1):26–30. doi: 10.1128/jcm.31.1.26-30.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Radford A. J. Mycobacterium ulcerans in Australia. Aust N Z J Med. 1975 Apr;5(2):162–169. doi: 10.1111/j.1445-5994.1975.tb03649.x. [DOI] [PubMed] [Google Scholar]
  26. Ramakrishnan L., Valdivia R. H., McKerrow J. H., Falkow S. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb;65(2):767–773. doi: 10.1128/iai.65.2.767-773.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sompolinsky D., Lagziel A., Rosenberg I. Further studies of a new pathogenic mycobacterium (M. haemophilum sp. nov.). Can J Microbiol. 1979 Feb;25(2):217–226. doi: 10.1139/m79-033. [DOI] [PubMed] [Google Scholar]
  28. Straus W. L., Ostroff S. M., Jernigan D. B., Kiehn T. E., Sordillo E. M., Armstrong D., Boone N., Schneider N., Kilburn J. O., Silcox V. A. Clinical and epidemiologic characteristics of Mycobacterium haemophilum, an emerging pathogen in immunocompromised patients. Ann Intern Med. 1994 Jan 15;120(2):118–125. doi: 10.7326/0003-4819-120-2-199401150-00004. [DOI] [PubMed] [Google Scholar]
  29. Tchornobay A. M., Claudy A. L., Perrot J. L., Lévigne V., Denis M. Fatal disseminated Mycobacterium marinum infection. Int J Dermatol. 1992 Apr;31(4):286–287. doi: 10.1111/j.1365-4362.1992.tb03575.x. [DOI] [PubMed] [Google Scholar]
  30. Wendt S. L., George K. L., Parker B. C., Gruft H., Falkinham J. O., 3rd Epidemiology of infection by nontuberculous Mycobacteria. III. Isolation of potentially pathogenic mycobacteria from aerosols. Am Rev Respir Dis. 1980 Aug;122(2):259–263. doi: 10.1164/arrd.1980.122.2.259. [DOI] [PubMed] [Google Scholar]
  31. Wolinsky E., Rynearson T. K. Mycobacteria in soil and their relation to disease-associated strains. Am Rev Respir Dis. 1968 Jun;97(6):1032–1037. doi: 10.1164/arrd.1968.97.6P1.1032. [DOI] [PubMed] [Google Scholar]

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