Abstract
To assess whether the Mycobacterium tuberculosis Beijing genotype is emerging in Vietnam, we analyzed 563 isolates from new cases by spoligotyping and examined the association between the genotype and age, resistance, and BCG vaccination status. Three hundred one (54%) patients were infected with Beijing genotype strains. The genotype was associated with younger age (and hence with active transmission) and with isoniazid and streptomycin resistance, but not with BCG vaccination.
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- Bifani P. J., Plikaytis B. B., Kapur V., Stockbauer K., Pan X., Lutfey M. L., Moghazeh S. L., Eisner W., Daniel T. M., Kaplan M. H. Origin and interstate spread of a New York City multidrug-resistant Mycobacterium tuberculosis clone family. JAMA. 1996 Feb 14;275(6):452–457. [PubMed] [Google Scholar]
- Diaz R., Kremer K., de Haas P. E., Gomez R. I., Marrero A., Valdivia J. A., van Embden J. D., van Soolingen D. Molecular epidemiology of tuberculosis in Cuba outside of Havana, July 1994-June 1995: utility of spoligotyping versus IS6110 restriction fragment length polymorphism. Int J Tuberc Lung Dis. 1998 Sep;2(9):743–750. [PubMed] [Google Scholar]
- Kamerbeek J., Schouls L., Kolk A., van Agterveld M., van Soolingen D., Kuijper S., Bunschoten A., Molhuizen H., Shaw R., Goyal M. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol. 1997 Apr;35(4):907–914. doi: 10.1128/jcm.35.4.907-914.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marttila H. J., Soini H., Eerola E., Vyshnevskaya E., Vyshnevskiy B. I., Otten T. F., Vasilyef A. V., Viljanen M. K. A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia. Antimicrob Agents Chemother. 1998 Sep;42(9):2443–2445. doi: 10.1128/aac.42.9.2443. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Netto E. M., Dye C., Raviglione M. C. Progress in global tuberculosis control 1995-1996, with emphasis on 22 high-incidence countries. Global Monitoring and Surveillance Project. Int J Tuberc Lung Dis. 1999 Apr;3(4):310–320. [PubMed] [Google Scholar]
- Qian L., Van Embden J. D., Van Der Zanden A. G., Weltevreden E. F., Duanmu H., Douglas J. T. Retrospective analysis of the Beijing family of Mycobacterium tuberculosis in preserved lung tissues. J Clin Microbiol. 1999 Feb;37(2):471–474. doi: 10.1128/jcm.37.2.471-474.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van Loo I. H., van der Heide H. G., Nagelkerke N. J., Verhoef J., Mooi F. R. Temporal trends in the population structure of Bordetella pertussis during 1949-1996 in a highly vaccinated population. J Infect Dis. 1999 Apr;179(4):915–923. doi: 10.1086/314690. [DOI] [PubMed] [Google Scholar]
- van Soolingen D., Borgdorff M. W., de Haas P. E., Sebek M. M., Veen J., Dessens M., Kremer K., van Embden J. D. Molecular epidemiology of tuberculosis in the Netherlands: a nationwide study from 1993 through 1997. J Infect Dis. 1999 Sep;180(3):726–736. doi: 10.1086/314930. [DOI] [PubMed] [Google Scholar]
- van Soolingen D., Qian L., de Haas P. E., Douglas J. T., Traore H., Portaels F., Qing H. Z., Enkhsaikan D., Nymadawa P., van Embden J. D. Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia. J Clin Microbiol. 1995 Dec;33(12):3234–3238. doi: 10.1128/jcm.33.12.3234-3238.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]