Skip to main content
NCBI home page
Emerging Infectious Diseases logoLink to Emerging Infectious Diseases
. 2000 Nov-Dec;6(6):572–575. doi: 10.3201/eid0606.000604

Trends in antimicrobial-drug resistance in Japan.

Y Arakawa 1, Y Ike 1, M Nagasawa 1, N Shibata 1, Y Doi 1, K Shibayama 1, T Yagi 1, T Kurata 1
PMCID: PMC2640928  PMID: 11076714

Abstract

Multidrug resistance in gram-positive bacteria has become common worldwide. In Japan until recently, gram-negative bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Serratia marcescens were controlled by carbapenems, fluoroquinolones, and aminoglycosides. However, several of these microorganisms have recently developed resistance against many antimicrobial drugs.

Full Text

The Full Text of this article is available as a PDF (28.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asahi Y., Ubukata K. Association of a thr-371 substitution in a conserved amino acid motif of penicillin-binding protein 1A with penicillin resistance of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1998 Sep;42(9):2267–2273. doi: 10.1128/aac.42.9.2267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Fujimura S., Tokue Y., Takahashi H., Nukiwa T., Hisamichi K., Mikami T., Watanabe A. A newly recognized acetylated metabolite of arbekacin in arbekacin-resistant strains of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1998 Apr;41(4):495–497. doi: 10.1093/jac/41.4.495. [DOI] [PubMed] [Google Scholar]
  3. Fujita N., Yoshimura M., Komori T., Tanimoto K., Ike Y. First report of the isolation of high-level vancomycin-resistant Enterococcus faecium from a patient in Japan. Antimicrob Agents Chemother. 1998 Aug;42(8):2150–2150. doi: 10.1128/aac.42.8.2150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hirakata Y., Izumikawa K., Yamaguchi T., Takemura H., Tanaka H., Yoshida R., Matsuda J., Nakano M., Tomono K., Maesaki S. Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother. 1998 Aug;42(8):2006–2011. doi: 10.1128/aac.42.8.2006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hiramatsu K., Aritaka N., Hanaki H., Kawasaki S., Hosoda Y., Hori S., Fukuchi Y., Kobayashi I. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet. 1997 Dec 6;350(9092):1670–1673. doi: 10.1016/S0140-6736(97)07324-8. [DOI] [PubMed] [Google Scholar]
  6. Hubert S. K., Mohammed J. M., Fridkin S. K., Gaynes R. P., McGowan J. E., Jr, Tenover F. C. Glycopeptide-intermediate Staphylococcus aureus: evaluation of a novel screening method and results of a survey of selected U.S. hospitals. J Clin Microbiol. 1999 Nov;37(11):3590–3593. doi: 10.1128/jcm.37.11.3590-3593.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ike Y., Tanimoto K., Ozawa Y., Nomura T., Fujimoto S., Tomita H. Vancomycin-resistant enterococci in imported chickens in Japan. Lancet. 1999 May 29;353(9167):1854–1854. doi: 10.1016/S0140-6736(99)01060-0. [DOI] [PubMed] [Google Scholar]
  8. Ikemoto H., Ito C., Yoshida T., Watanabe K., Mori T., Ohno I., Okada S., Igari J., Arakawa M., Igarashi K. [Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1997)]. Jpn J Antibiot. 1999 May;52(5):353–397. [PubMed] [Google Scholar]
  9. Ishii Y., Ohno A., Taguchi H., Imajo S., Ishiguro M., Matsuzawa H. Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from Escherichia coli. Antimicrob Agents Chemother. 1995 Oct;39(10):2269–2275. doi: 10.1128/aac.39.10.2269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ito H., Arakawa Y., Ohsuka S., Wacharotayankun R., Kato N., Ohta M. Plasmid-mediated dissemination of the metallo-beta-lactamase gene blaIMP among clinically isolated strains of Serratia marcescens. Antimicrob Agents Chemother. 1995 Apr;39(4):824–829. doi: 10.1128/aac.39.4.824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Izumiya H., Tamura K., Terajima J., Watanabe H. Salmonella enterica serovar. Typhimurium phage type DT104 and other multi-drug resistant strains in Japan. Jpn J Infect Dis. 1999 Jun;52(3):133–133. [PubMed] [Google Scholar]
  12. Kusachi S., Sumiyama Y., Nagao J., Kawai K., Arima Y., Yoshida Y., Kajiwara H., Saida Y., Nakamura Y. New methods of control against postoperative methicillin-resistant Staphylococcus aureus infection. Surg Today. 1999;29(8):724–729. doi: 10.1007/BF02482316. [DOI] [PubMed] [Google Scholar]
  13. Matsumoto K., Shiraishi T., Rikimaru T., Mimori Y., Kinoshita M., Oizumi K., Kajimura K., Kondo S. [Resistance against oral antibiotics to Streptococcus pneumoniae isolated from adult respiratory tract infections]. Kansenshogaku Zasshi. 1999 Dec;73(12):1187–1193. doi: 10.11150/kansenshogakuzasshi1970.73.1187. [DOI] [PubMed] [Google Scholar]
  14. Nakamura T., Uchida S., Heijyo H., Masuda M., Takahashi H., Komatsu M., Aihara M., Kurokawa H., Shibata N., Yagi T. [A SHV-derived extended-spectrum beta-lactamase (SHV-12) produced by an Escherichia coli recovered from wound abscess in post operative case with rectal carcinoma]. Kansenshogaku Zasshi. 2000 Feb;74(2):112–119. doi: 10.11150/kansenshogakuzasshi1970.74.112. [DOI] [PubMed] [Google Scholar]
  15. Oguri T., Misawa S., Nakamura A., Igari J. [The procedures for detection of penicillin-resistant Streptococcus pneumoniae and the epidemiology]. Rinsho Byori. 2000 Jan;Suppl 111:48–55. [PubMed] [Google Scholar]
  16. Ohkusu K., Nakamura A., Sawada K. Antibiotic resistance among recent clinical isolates of Haemophilus influenzae in Japanese children. Diagn Microbiol Infect Dis. 2000 Apr;36(4):249–254. doi: 10.1016/s0732-8893(99)00147-9. [DOI] [PubMed] [Google Scholar]
  17. Sasaki Y., Yamagishi F., Mizutani F., Yagi T., Kuroda F., Wada A. [Outbreak of multidrug-resistant Mycobacterium tuberculosis infection in the middle and advanced age]. Kekkaku. 1999 Jul;74(7):549–553. [PubMed] [Google Scholar]
  18. Senda K., Arakawa Y., Ichiyama S., Nakashima K., Ito H., Ohsuka S., Shimokata K., Kato N., Ohta M. PCR detection of metallo-beta-lactamase gene (blaIMP) in gram-negative rods resistant to broad-spectrum beta-lactams. J Clin Microbiol. 1996 Dec;34(12):2909–2913. doi: 10.1128/jcm.34.12.2909-2913.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Senda K., Arakawa Y., Nakashima K., Ito H., Ichiyama S., Shimokata K., Kato N., Ohta M. Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including carbapenems. Antimicrob Agents Chemother. 1996 Feb;40(2):349–353. doi: 10.1128/aac.40.2.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Takeda S., Yasunaka K., Kono K., Arakawa K. Methicillin-resistant Staphylococcus aureus (MRSA) isolated at Fukuoka University Hospital and hospitals and clinics in the Fukuoka city area. Int J Antimicrob Agents. 2000 Feb;14(1):39–43. doi: 10.1016/s0924-8579(99)00148-x. [DOI] [PubMed] [Google Scholar]
  21. Takenouchi T., Sakagawa E., Sugawara M. Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones. Antimicrob Agents Chemother. 1999 Feb;43(2):406–409. doi: 10.1128/aac.43.2.406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tanaka M., Nakayama H., Haraoka M., Saika T. Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998. J Clin Microbiol. 2000 Feb;38(2):521–525. doi: 10.1128/jcm.38.2.521-525.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tsurumaki Y., Manda H., Takei M., Hosaka M. In vitro antimicrobial activity of gatifloxacin against 873 clinical isolates from respiratory tract, urinary tract and surgical infections during 1997-1998 in Japan. J Antimicrob Chemother. 2000 May;45(5):685–689. doi: 10.1093/jac/45.5.685. [DOI] [PubMed] [Google Scholar]
  24. Yagi T., Kurokawa H., Senda K., Ichiyama S., Ito H., Ohsuka S., Shibayama K., Shimokata K., Kato N., Ohta M. Nosocomial spread of cephem-resistant Escherichia coli strains carrying multiple Toho-1-like beta-lactamase genes. Antimicrob Agents Chemother. 1997 Dec;41(12):2606–2611. doi: 10.1128/aac.41.12.2606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Yagi T., Kurokawa H., Shibata N., Shibayama K., Arakawa Y. A preliminary survey of extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Klebsiella pneumoniae and Escherichia coli in Japan. FEMS Microbiol Lett. 2000 Mar 1;184(1):53–56. doi: 10.1111/j.1574-6968.2000.tb08989.x. [DOI] [PubMed] [Google Scholar]
  26. Yamaguchi K., Ohno A., Kashitani F., Iwata M., Shimizu Y., Sato S., Matsumoto I., Itoh M., Funato T., Tsujio Y. [In vitro activities of 23 antimicrobial agents against 4,993 gram-positive and gram-negative bacterial strains isolated from multicenter of Japan during 1994--in vitro susceptibility surveillance.Levofloxacin-Surveillance Group]. Jpn J Antibiot. 1999 Feb;52(2):75–92. [PubMed] [Google Scholar]

Articles from Emerging Infectious Diseases are provided here courtesy of Centers for Disease Control and Prevention

RESOURCES