Abstract
The first case of osteomyelitis caused by Neosartorya pseudofischeri is reported. The patient, a 77-year-old male with a history of silicosis and tuberculosis, on X-ray examination revealed lytic lesions of L2 and L3 vertebrae suspicious for metastatic lesions. Histologic examination of biopsy specimens from vertebral bodies showed short, distorted, extra- and intracellular, hyaline hyphal fragments. The culture from the biopsy tissue produced numerous, evanescent asci containing eight ellipsoidal ascospores with two distinctive equatorial bands ca. 1 micron wide. When examined by a scanning electron microscope, ascospores exhibited a convex surface ornamented with raised flaps of tissue, in shape resembling triangular projections or long ridge lines. The conidial state (anamorph) was identified as Aspergillus thermomutatus on the basis of conidial columns which were smaller and less tightly packed as well as of a lighter shade of green than those observed in Aspergillus fumigatus. On the basis of the morphologic features of the ascospores, the teleomorph was identified as N. pseudofischeri.
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- Bodey G. P., Vartivarian S. Aspergillosis. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):413–437. doi: 10.1007/BF01964057. [DOI] [PubMed] [Google Scholar]
- Coriglione G., Stella G., Gafa L., Spata G., Oliveri S., Padhye A. A., Ajello L. Neosartorya fischeri var fischeri (Wehmer) Malloch and Cain 1972 (anamorph: Aspergillus fischerianus Samson and Gams 1985) as a cause of mycotic keratitis. Eur J Epidemiol. 1990 Dec;6(4):382–385. doi: 10.1007/BF00151712. [DOI] [PubMed] [Google Scholar]
- Gerber J., Chomicki J., Brandsberg J. W., Jones R., Hammerman K. J. Pulmonary aspergillosis caused by Aspergillus fischeri var. spinosus: report of a case and value of serologic studies. Am J Clin Pathol. 1973 Dec;60(6):861–866. doi: 10.1093/ajcp/60.6.861. [DOI] [PubMed] [Google Scholar]
- Glotzbach R. E. Aspergillus terreus infection of pseudoaneurysm of aortofemoral vascular graft with contiguous vertebral osteomyelitis. Am J Clin Pathol. 1982 Feb;77(2):224–227. doi: 10.1093/ajcp/77.2.224. [DOI] [PubMed] [Google Scholar]
- Rinaldi M. G. Invasive aspergillosis. Rev Infect Dis. 1983 Nov-Dec;5(6):1061–1077. doi: 10.1093/clinids/5.6.1061. [DOI] [PubMed] [Google Scholar]
- Roselle G. A., Baird I. M. Aspergillus flavipes group osteomyelitis. Arch Intern Med. 1979 May;139(5):590–592. [PubMed] [Google Scholar]
- Simpson M. B., Jr, Merz W. G., Kurlinski J. P., Solomon M. H. Opportunistic mycotic osteomyelitis: bone infections due to Aspergillus and Candida species. Medicine (Baltimore) 1977 Nov;56(6):475–482. [PubMed] [Google Scholar]
- Summerbell R. C., de Repentigny L., Chartrand C., St Germain G. Graft-related endocarditis caused by Neosartorya fischeri var. spinosa. J Clin Microbiol. 1992 Jun;30(6):1580–1582. doi: 10.1128/jcm.30.6.1580-1582.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tack K. J., Rhame F. S., Brown B., Thompson R. C., Jr Aspergillus osteomyelitis. Report of four cases and review of the literature. Am J Med. 1982 Aug;73(2):295–300. doi: 10.1016/0002-9343(82)90192-9. [DOI] [PubMed] [Google Scholar]