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. 1984 Mar;43(3):783–790. doi: 10.1128/iai.43.3.783-790.1984

Effect of C3 depletion on experimental Pseudomonas aeruginosa ocular infection: histopathological analysis.

L D Hazlett, R S Berk
PMCID: PMC264248  PMID: 6698607

Abstract

The ocular histopathological response of C3-depleted and normal DBA/2J mice was compared after corneal scarification and experimental infection with topically applied Pseudomonas aeruginosa. Normal, non-C3-depleted mice were capable of mounting a vigorous polymorphonuclear leukocyte response at 24 h after bacterial challenge and eventually restored corneal clarity. In contrast, C3-depleted animals responded at 24 h to the ocular bacterial challenge with a decreased number of polymorphonuclear leukocytes migrating into the cornea. Additionally, the eyes of C3-depleted mice exhibited persistence of bacteria, cataract of the ocular lens, and loss of vision.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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