Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1984 Mar;43(3):856–859. doi: 10.1128/iai.43.3.856-859.1984

Persistent Cryptosporidium infection in congenitally athymic (nude) mice.

J Heine, H W Moon, D B Woodmansee
PMCID: PMC264261  PMID: 6607888

Abstract

Nude (nu/nu) BALB/c mice and their white (nu/+) littermates were experimentally infected with Cryptosporidium sp. at 6 days of age. In white mice, the infection was transient, but in nude mice a persistent infection developed that was characterized by diarrhea and, occasionally, death. There were villus atrophy and crypt hyperplasia in the small intestine of infected nude and white mice necropsied at 11 days of age. Persistently infected nude mice had, in addition to the above small intestinal lesions, diffuse cystic mucosal hyperplasia and crypt abscesses in the large intestine at 56 days of age. These results suggest that T cells are required for recovery from the Cryptosporidium infection but are not required for epithelial cell loss in cryptosporidiosis. Both nude and white mice appeared to be relatively more resistant to Cryptosporidium infection at 42 days of age than at 6 days of age.

Full text

PDF
856

Images in this article

858Image
on p.858

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson B. C., Donndelinger T., Wilkins R. M., Smith J. Cryptosporidiosis in a veterinary student. J Am Vet Med Assoc. 1982 Feb 15;180(4):408–409. [PubMed] [Google Scholar]
  2. Angus K. W., Tzipori S., Gray E. W. Intestinal lesions in specific-pathogen-free lambs associated with a cryptosporidium from calves with diarrhea. Vet Pathol. 1982 Jan;19(1):67–78. doi: 10.1177/030098588201900110. [DOI] [PubMed] [Google Scholar]
  3. Boch J., Göbel E., Heine J., Brändler U., Schloemer L. Kryptosporidien-Infektion bei Haustieren. Berl Munch Tierarztl Wochenschr. 1982 Oct 1;95(19):361–367. [PubMed] [Google Scholar]
  4. Brownstein D. G., Strandberg J. D., Montali R. J., Bush M., Fortner J. Cryptosporidium in snakes with hypertrophic gastritis. Vet Pathol. 1977 Nov;14(6):606–617. doi: 10.1177/030098587701400607. [DOI] [PubMed] [Google Scholar]
  5. Current W. L., Reese N. C., Ernst J. V., Bailey W. S., Heyman M. B., Weinstein W. M. Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission. N Engl J Med. 1983 May 26;308(21):1252–1257. doi: 10.1056/NEJM198305263082102. [DOI] [PubMed] [Google Scholar]
  6. Essex M., McLane M. F., Lee T. H., Falk L., Howe C. W., Mullins J. I., Cabradilla C., Francis D. P. Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science. 1983 May 20;220(4599):859–862. doi: 10.1126/science.6342136. [DOI] [PubMed] [Google Scholar]
  7. Heine J., Boch J. Kryptosporidien-Infektionen beim Kalb. Nachweis, Vorkommen und experimentelle Ubertragung. Berl Munch Tierarztl Wochenschr. 1981 Aug 1;94(15):289–292. [PubMed] [Google Scholar]
  8. Heine J. Eine einfache Nachweismethode für Kryptosporidien im Kot. Zentralbl Veterinarmed B. 1982 May;29(4):324–327. [PubMed] [Google Scholar]
  9. Klesius P. H., Hinds S. E. Strain-dependent differences in murine susceptibility to coccidia. Infect Immun. 1979 Dec;26(3):1111–1115. doi: 10.1128/iai.26.3.1111-1115.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mesfin G. M., Bellamy J. E. Thymic dependence of immunity to Eimeria falciformis var. pragensis in mice. Infect Immun. 1979 Feb;23(2):460–464. doi: 10.1128/iai.23.2.460-464.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Moon H. W., Bemrick W. J. Fecal transmission of calf cryptosporidia between calves and pigs. Vet Pathol. 1981 Mar;18(2):248–255. doi: 10.1177/030098588101800213. [DOI] [PubMed] [Google Scholar]
  12. Roberts-Thomson I. C., Mitchell G. F. Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice. Gastroenterology. 1978 Jul;75(1):42–46. [PubMed] [Google Scholar]
  13. Rose M. E., Hesketh P. Coccidiosis: T-lymphocyte-dependent effects of infection with Eimeria nieschulzi in rats. Vet Immunol Immunopathol. 1982 Sep;3(5):499–508. doi: 10.1016/0165-2427(82)90015-0. [DOI] [PubMed] [Google Scholar]
  14. Rose M. E., Hesketh P. Immunity to coccidiosis: T-lymphocyte- or B-lymphocyte-deficient animals. Infect Immun. 1979 Nov;26(2):630–637. doi: 10.1128/iai.26.2.630-637.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sherwood D., Angus K. W., Snodgrass D. R., Tzipori S. Experimental cryptosporidiosis in laboratory mice. Infect Immun. 1982 Nov;38(2):471–475. doi: 10.1128/iai.38.2.471-475.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stein E., Boch J., Heine J., Henkel G. Der Verlauf natürlicher Cryptosporidium-Infektionen in vier Rinderzuchtbetrieben. Berl Munch Tierarztl Wochenschr. 1983 Jul 1;96(7):222–225. [PubMed] [Google Scholar]
  17. Tzipori S. Cryptosporidiosis in animals and humans. Microbiol Rev. 1983 Mar;47(1):84–96. doi: 10.1128/mr.47.1.84-96.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tzipori S., Smith M., Halpin C., Angus K. W., Sherwood D., Campbell I. Experimental cryptosporidiosis in calves: clinical manifestations and pathological findings. Vet Rec. 1983 Feb 5;112(6):116–120. doi: 10.1136/vr.112.6.116. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES