Table 1.
Rat Behavioral Testing Protocol
| Cohort | Group | N | Treatment | Days of Drug Exposure/Procedure Conducted | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 8–14 | 15–60 | 22–28 | 39–45 | 50–53 | 83–90 | 174–180 | ||||
| 1 | A | 6 | VEHICLE | WM | WM | WM | Motor | WM | ||
| B | 6 | CPZ 10.0 mg/kg/day | WM | WM | WM | Motor | WM | |||
| C | 6 | OLZ 10.0 mg/kg/day | WM | WM | WM | Motor | WM | |||
| 2 | D | 6 | VEHICLE | WM | WM | WM | Motor | WM | WM | |
| E | 6 | CPZ 10.0 mg/kg/day | WM | WM | WM | Motor | WM | WM | ||
| F | 6 | OLZ 10.0 mg/kg/day | WM | WM | WM | Motor | WM | WM | ||
| 3 | G | 6 | VEHICLE | RAM | ||||||
| H | 6 | CPZ 5.0 mg/kg/day | RAM | |||||||
| I | 6 | OLZ 5.0 mg/kg/day | RAM | |||||||
| 4 | J | 6 | VEHICLE | RAM | ||||||
| K | 6 | CPZ 5.0 mg/kg/day | RAM | |||||||
| L | 6 | OLZ 5.0 mg/kg/day | RAM | |||||||
| 5 | M | 6 | VEHICLE | RAM | ||||||
| N | 6 | CPZ 10.0 mg/kg/day | RAM | |||||||
| O | 6 | OLZ 10.0 mg/kg/day | RAM | |||||||
| 6 | P | 6 | VEHICLE | RAM | ||||||
| Q | 6 | CPZ 10.0 mg/kg/day | RAM | |||||||
| R | 6 | OLZ 10.0 mg/kg/day | RAM | |||||||
CPZ = chlorpromazine; OLZ = olanzapine; WM =water maze; RAM= radial arm maze; Motor = motor function tests (open field, rotor-rod, and grip strength)