Table 3.
Test Group | Dose/24 hr | Compound Measured | Plasma Concentration (ng/mL )± S.E.M. N=4–6 |
Estimated Human Therapeutic Plasma Range (ng/mL)* | ||
---|---|---|---|---|---|---|
45 Days | 90 days | 180 days | ||||
chlorpromazine | 10.0 mg/kg | chlorpromazine | 6.2 ± 2.1 | 15.4 ± 2.9 | 11.9 ± 2.8 | 25–350 (or unknown) |
olanzapine | 10.0 mg/kg | olanzapine | 23.7 ± 8.9 | 31.0 ± 9.9 | 22.6 ± 7.5 | 9.0–80.0 |
Estimated human therapeutic plasma ranges listed are based on Curry et al., 1970; Baldessarini et al., 1988; Chetty et al., 1996; Perry et al., 2001; Rao et al., 2001; Gex-Fabry-Fabry et al., 2003.