Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1984 Mar;43(3):925–930. doi: 10.1128/iai.43.3.925-930.1984

Resistance to subcutaneous infection with Mycobacterium lepraemurium is controlled by more than one gene.

J Curtis, J L Turk
PMCID: PMC264272  PMID: 6365787

Abstract

The resistance of C57BL (high) and BALB/c (low) mice, their F1 hybrids, and the offspring derived from backcrosses of the F1 to both parental strains was assessed at 20 weeks after subcutaneous infection with 10(7) Mycobacterium lepraemurium organisms. The numbers of bacilli recovered from the infected foot and draining lymph node indicated that resistance to subcutaneous infection is controlled by more than one non-H-2-linked gene of intermediate dominance. In general, female mice were more resistant than males.

Full text

PDF
925

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander J. Adoptive transfer of immunity and suppression by cells and serum in early Mycobacterium lepraemurium infections of mice. Parasite Immunol. 1979 Summer;1(2):159–166. doi: 10.1111/j.1365-3024.1979.tb00703.x. [DOI] [PubMed] [Google Scholar]
  2. Blackwell J., Freeman J., Bradley D. Influence of H-2 complex on acquired resistance to Leishmania donovani infection in mice. Nature. 1980 Jan 3;283(5742):72–74. doi: 10.1038/283072a0. [DOI] [PubMed] [Google Scholar]
  3. Bradley D. J. Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin Exp Immunol. 1977 Oct;30(1):130–140. [PMC free article] [PubMed] [Google Scholar]
  4. Brown I. N., Glynn A. A., Plant J. Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity/Lsh pattern. Immunology. 1982 Sep;47(1):149–156. [PMC free article] [PubMed] [Google Scholar]
  5. Cheers C., McKenzie I. F. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun. 1978 Mar;19(3):755–762. doi: 10.1128/iai.19.3.755-762.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Curtis J., Adu H. O., Turk J. L. A lack of correlation between antigen-specific cellular reactions and resistance to Mycobacterium lepraemurium infection in mice. Immunology. 1981 Jun;43(2):293–301. [PMC free article] [PubMed] [Google Scholar]
  7. Curtis J., Adu H. O., Turk J. L. H-2 linkage control of resistance to subcutaneous infection with Mycobacterium lepraemurium. Infect Immun. 1982 Nov;38(2):434–439. doi: 10.1128/iai.38.2.434-439.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Draper P. The walls of Mycobacterium lepraemurium: chemistry and ultrastructure. J Gen Microbiol. 1971 Dec;69(3):313–324. doi: 10.1099/00221287-69-3-313. [DOI] [PubMed] [Google Scholar]
  9. Gros P., Skamene E., Forget A. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol. 1981 Dec;127(6):2417–2421. [PubMed] [Google Scholar]
  10. HART P. D., REES R. J. Effect of macrocyclon in acute and chronic pulmonary tuberculous infection in mice as shown by viable and total bacterial counts. Br J Exp Pathol. 1960 Aug;41:414–421. [PMC free article] [PubMed] [Google Scholar]
  11. Howard J. G., Hale C., Chan-Liew W. L. Immunological regulation of experimental cutaneous leishmaniasis. 1. Immunogenetic aspects of susceptibility to Leishmania tropica in mice. Parasite Immunol. 1980 Winter;2(4):303–314. doi: 10.1111/j.1365-3024.1980.tb00061.x. [DOI] [PubMed] [Google Scholar]
  12. KAWAGUCHI Y. Classification of mouse leprosy. Jpn J Exp Med. 1959 Dec;29:651–663. [PubMed] [Google Scholar]
  13. Lefford M. J., Patel P. J., Poulter L. W., Mackaness G. B. Induction of cell-mediated immunity to Mycobacterium lepraemurium in susceptible mice. Infect Immun. 1977 Dec;18(3):654–659. doi: 10.1128/iai.18.3.654-659.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Nakamura R. M., Tokunaga T. Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice. Infect Immun. 1978 Dec;22(3):657–664. doi: 10.1128/iai.22.3.657-664.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. O'Brien A. D., Rosenstreich D. L., Scher I., Campbell G. H., MacDermott R. P., Formal S. B. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol. 1980 Jan;124(1):20–24. [PubMed] [Google Scholar]
  16. Plant J. E., Blackwell J. M., O'Brien A. D., Bradley D. J., Glynn A. A. Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1? Nature. 1982 Jun 10;297(5866):510–511. doi: 10.1038/297510a0. [DOI] [PubMed] [Google Scholar]
  17. Plant J., Glynn A. A. Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis. 1976 Jan;133(1):72–78. doi: 10.1093/infdis/133.1.72. [DOI] [PubMed] [Google Scholar]
  18. Preston P. M. Macrophages and protective immunity in Mycobacterium lepraemurium infections in a 'resistant' (C57Bl) and a 'susceptible' (BALB/c) mouse strain. Clin Exp Immunol. 1982 Feb;47(2):243–252. [PMC free article] [PubMed] [Google Scholar]
  19. Skamene E., Gros P., Forget A., Kongshavn P. A., St Charles C., Taylor B. A. Genetic regulation of resistance to intracellular pathogens. Nature. 1982 Jun 10;297(5866):506–509. doi: 10.1038/297506a0. [DOI] [PubMed] [Google Scholar]
  20. Skamene E., Kongshavn P. A. Phenotypic expression of genetically controlled host resistance to Listeria monocytogenes. Infect Immun. 1979 Jul;25(1):345–351. doi: 10.1128/iai.25.1.345-351.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stevenson M. M., Lyanga J. J., Skamene E. Murine malaria: genetic control of resistance to Plasmodium chabaudi. Infect Immun. 1982 Oct;38(1):80–88. doi: 10.1128/iai.38.1.80-88.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Trischmann T. M., Bloom B. R. Genetics of murine resistance to Trypanosoma cruzi. Infect Immun. 1982 Feb;35(2):546–551. doi: 10.1128/iai.35.2.546-551.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES