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. 1984 Feb;43(2):589–592. doi: 10.1128/iai.43.2.589-592.1984

B-cell function in vitro during rubella infection.

T Hyypiä, J Eskola, M Laine, O Meurman
PMCID: PMC264339  PMID: 6607217

Abstract

B-cell function in vitro was studied in patients with natural rubella virus infection. Lymphocyte responses to mitogens in a blast transformation test were decreased at the onset of the rash. Spontaneous immunoglobulin production by peripheral blood lymphocytes was increased during the acute phase of illness. In regulatory T-cell subpopulations, increased proportions of cells with suppressor/cytotoxic phenotypes and decreased proportions of cells with helper/inducer phenotypes were detected simultaneously with the increased spontaneous immunoglobulin production. All parameters studied were recovered during the convalescent phase.

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Selected References

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