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. 1984 Feb;43(2):761–764. doi: 10.1128/iai.43.2.761-764.1984

Glycoprotein D protects mice against lethal challenge with herpes simplex virus types 1 and 2.

D Long, T J Madara, M Ponce de Leon, G H Cohen, P C Montgomery, R J Eisenberg
PMCID: PMC264368  PMID: 6319291

Abstract

Glycoprotein D is a virion envelope component of herpes simplex virus types 1 and 2. Sets of mice were immunized with purified gD-1 or gD-2 and were challenged with a lethal dose of herpes simple virus, either type 1 or type 2. All or virtually all of the immunized mice survived challenge with either agent, whereas challenge of sham-immunized mice was almost always fatal. Serum samples taken before challenge contained gD-specific antibodies which had 50% neutralization titers ranging from 1:16 to 1:512 against homologous and heterologous virus types. We conclude that either gD-1 or gD-2 is a potential candidate for a subunit vaccine against herpetic infections.

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Selected References

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