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. 1983 Dec;42(3):1183–1186. doi: 10.1128/iai.42.3.1183-1186.1983

Effect of Clostridium perfringens epsilon toxin on the cardiovascular system of rats.

J Sakurai, M Nagahama, Y Fujii
PMCID: PMC264423  PMID: 6315593

Abstract

Pressor activity was demonstrated by the intravenous injection of purified epsilon toxin of Clostridium perfringens type D but not by that of epsilon prototoxin. The activity was completely abolished by C. perfringens type B or D antiserum, but not by type A, C, or E antiserum. The rise in blood pressure caused by the toxin was accompanied by a decrease in the blood flow in skin without any change of heart rate and electrocardiogram readings. These results indicate that epsilon toxin possesses pressor activity as well as lethal and dermonecrotic activities.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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