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. 1983 Dec;42(3):1191–1194. doi: 10.1128/iai.42.3.1191-1194.1983

Inhibition of keratinocyte proliferation by extracts of Actinobacillus actinomycetemcomitans.

P R Kamen
PMCID: PMC264425  PMID: 6196295

Abstract

A heat-labile sonic extract of a nonleukotoxic strain of Actinobacillus actinomycetemcomitans caused a dose-dependent inhibition of proliferation of human keratinocytes. Exposure of cells to heat-labile sonic extract for periods as brief as 10 min produced significant suppression of [3H]thymidine uptake 72 h later. I propose that alteration of epithelial barriers may be one pathogenic mechanism of this organism.

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Selected References

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