Abstract
The B (nondiabetogenic) and D (diabetogenic) variants of encephalomyocarditis (EMC) virus were studied to further define the role of the interferon (IFN) system in murine virus-induced diabetes mellitus. The relationship between the initial multiplicity of infection with EMC-B and the IFN yield showed that cells infected with one IFN-inducing particle produce a maximum amount of IFN, whereas IFN production is suppressed in cells infected with two or more particles. The IFN yield induced by EMC-D was less than 5% of that induced by EMC-B, allowing the designation of the B and D variants as Ifp+ and Ifp-, respectively. The Ifp+ property of the virion was shown to be responsible for the greater sensitivity of EMC-B to exogenous IFN as a result of primed local IFN induction. The data indicate that different Ifp phenotypes occur in nature and are associated with the development of diabetes in mice.
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- Craighead J. E., McLane M. F. Diabetes mellitus: induction in mice by encephalomyocarditis virus. Science. 1968 Nov 22;162(3856):913–914. doi: 10.1126/science.162.3856.913. [DOI] [PubMed] [Google Scholar]
- ISAACS A., BURKE D. C. Mode of action of interferon. Nature. 1958 Oct 18;182(4642):1073–1074. doi: 10.1038/1821073a0. [DOI] [PubMed] [Google Scholar]
- Jordan G. W., Merigan T. C. Quantitative aspects of interferon-induced plaque reduction: effects of cell age and dose of challenge virus. Proc Soc Exp Biol Med. 1974 Mar;145(3):1037–1041. doi: 10.3181/00379727-145-37948. [DOI] [PubMed] [Google Scholar]
- Marcus P. I., Guidon P. T., Jr, Sekellick M. J. Interferon induction by viruses. VII. Mengovirus: "interferon-sensitive" mutant phenotype attributed to interferon-inducing particle activity. J Interferon Res. 1981;1(4):601–611. doi: 10.1089/jir.1981.1.601. [DOI] [PubMed] [Google Scholar]
- Marcus P. I. Interferon induction by viruses. IX. Antagonistic activities of virus particles modulated interferon production. J Interferon Res. 1982;2(4):511–518. doi: 10.1089/jir.1982.2.511. [DOI] [PubMed] [Google Scholar]
- Schafer T. W., Lockart R. Z., Jr Interferon required for viral resistance induced by poly I.poly C. Nature. 1970 May 2;226(5244):449–450. doi: 10.1038/226449a0. [DOI] [PubMed] [Google Scholar]
- Simon E. H., Kung S., Koh T. T., Brandman P. Interferon-sensitive mutants of mengovirus. I. Isolation and biological characterization. Virology. 1976 Feb;69(2):727–736. doi: 10.1016/0042-6822(76)90501-8. [DOI] [PubMed] [Google Scholar]
- Stewart W. E., 2nd, Gosser L. B., Lockart R. Z., Jr Priming: a nonantiviral function of interferon. J Virol. 1971 Jun;7(6):792–801. doi: 10.1128/jvi.7.6.792-801.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vengris V. E., Stollar B. D., Pitha P. M. Interferon externalization by producing cell before induction of antiviral state. Virology. 1975 Jun;65(2):410–417. doi: 10.1016/0042-6822(75)90046-x. [DOI] [PubMed] [Google Scholar]
- Yoon J. W., Cha C. Y., Jordan G. W. The role of interferon in virus-induced diabetes. J Infect Dis. 1983 Jan;147(1):155–159. doi: 10.1093/infdis/147.1.155. [DOI] [PubMed] [Google Scholar]
- Yoon J. W., McClintock P. R., Onodera T., Notkins A. L. Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus. J Exp Med. 1980 Oct 1;152(4):878–892. doi: 10.1084/jem.152.4.878. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoon J., Onodera T., Notkins A. L. Virus-induced diabetes mellitus: VIII. Passage of encephalomyocarditis virus and severity of diabetes in susceptible and resistant strains of mice. J Gen Virol. 1977 Nov;37(2):225–232. doi: 10.1099/0022-1317-37-2-225. [DOI] [PubMed] [Google Scholar]