Figure 5.—

alph inactivation increases UV-induced retinal apoptosis in a JNK-dependent manner. (A–D) Photomicrographs of adult fly eyes (top and side views) of the indicated genotypes that either were UV irradiated (+UV, left eye) or were not (−UV, right eye) during pupal development. (E) Tissue loss following UV irradiation is quantified by determining the ratio between the eye area of the irradiated eye (left, L) to the one of the non-irradiated eye (right, R). Means ± standard deviations for the L/R ratios of at least 10 heads/genotype are depicted as bar graphs. Statistical significance was confirmed using a Student's t-test. Canton-S flies were used as wild-type (WT) controls. Identical results were obtained when using isogenic w¹¹¹⁸ flies as controls (not shown).