The ethanol tolerance as percentage of survival of Mdh1, Adh, and Gpdh di-locus genotypes. No experiments found statistically significant interactions. (A) Experiment 6 using Mdh1 and Adh genotypes with ratios of 50:50 (n = 15), 50:100 (n = 23), 100:50 (n = 16), and 100:100 (n = 26) normal activities. There are significant Mdh genotype effects (****P < 0.0001) and significant Adh genotype effects (*P < 0.017). (B) Experiment 7 using Mdh1 and Gpdh genotypes with ratios of 50:50 (n = 22), 50:100 (n = 34), 100:50 (n = 27), and 100:100 (n = 29) normal activities. There are significant Mdh genotype effects (*P < 0.038). (C) Experiment 8 using the Gpdh and Adh genotypes with ratios of 50:50 (n = 28), 50:100 (n = 34), 100:50 (n = 25), and 100:100 (n = 27) normal activities. Neither Gpdh nor Adh genotype effects were significant. The expected relative activities of genotypes are shown inside parentheses. Error bars represent ±1 SE.