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. 1983 Sep;41(3):1016–1023. doi: 10.1128/iai.41.3.1016-1023.1983

Comparative pathogenicity of four strains of Aleutian disease virus for pastel and sapphire mink.

W J Hadlow, R E Race, R C Kennedy
PMCID: PMC264602  PMID: 6193063

Abstract

Information was sought on the comparative pathogenicity of four North American strains (isolates) of Aleutian disease virus for royal pastel (a non-Aleutian genotype) and sapphire (an Aleutian genotype) mink. The four strains (Utah-1, Ontario [Canada], Montana, and Pullman [Washington]), all of mink origin, were inoculated intraperitoneally and intranasally in serial 10-fold dilutions. As indicated by the appearance of specific antibody (counterimmunoelectrophoresis test), all strains readily infected both color phases of mink, and all strains were equally pathogenic for sapphire mink. Not all strains, however, regularly caused Aleutian disease in pastel mink. Infection of pastel mink with the Utah-1 strain invariably led to fatal disease. Infection with the Ontario strain caused fatal disease nearly as often. The Pullman strain, by contrast, almost never caused disease in infected pastel mink. The pathogenicity of the Montana strain for this color phase was between these extremes. These findings emphasize the need to distinguish between infection and disease when mink are exposed to Aleutian disease virus. The distinction has important implications for understanding the natural history of Aleutian disease virus infection in ranch mink.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. An S. H., DePauli F. J., Wright P., Ingram D. G. Characteristics of inapparent Aleutian disease virus infection in mink. Res Vet Sci. 1978 Mar;24(2):200–204. [PubMed] [Google Scholar]
  2. An S. H., Ingram D. G. Detection of inapparent Aleutian disease virus infection in mink. Am J Vet Res. 1977 Oct;38(10):1619–1624. [PubMed] [Google Scholar]
  3. An S. H., Ingram D. G. Transmission of Aleutian disease from mink with inapparent infections. Am J Vet Res. 1978 Feb;39(2):309–313. [PubMed] [Google Scholar]
  4. Bloom M. E., Race R. E., Hadlow W. J., Chesebro B. Aleutian disease of mink: the antibody response of sapphire and pastel mink to Aleutian disease virus. J Immunol. 1975 Oct;115(4):1034–1037. [PubMed] [Google Scholar]
  5. Bloom M. E., Race R. E., Wolfinbarger J. B. Characterization of Aleutian disease virus as a parvovirus. J Virol. 1980 Sep;35(3):836–843. doi: 10.1128/jvi.35.3.836-843.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cho H. J., Greenfield J. Eradication of Aleutian disease of mink by eliminating positive counterimmunoelectrophoresis test reactors. J Clin Microbiol. 1978 Jan;7(1):18–22. doi: 10.1128/jcm.7.1.18-22.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cho H. J., Ingram D. G. The antigen and virus of Aleutian disease in mink. J Immunol Methods. 1974 Mar;4(2):217–228. doi: 10.1016/0022-1759(74)90065-9. [DOI] [PubMed] [Google Scholar]
  8. Crawford T. B., McGuire T. C., Porter D. D., Cho H. J. A comparative study of detection methods for Aleutian disease viral antibody. J Immunol. 1977 Apr;118(4):1249–1251. [PubMed] [Google Scholar]
  9. Eklund C. M., Hadlow W. J., Kennedy R. C., Boyle C. C., Jackson T. A. Aleutian disease of mink: properties of the etiologic agent and the host responses. J Infect Dis. 1968 Dec;118(5):510–526. doi: 10.1093/infdis/118.5.510. [DOI] [PubMed] [Google Scholar]
  10. GORHAM J. R., LEADER R. W., HENSON J. B. THE EXPERIMENTAL TRANSMISSION OF A VIRUS CAUSING HYPERGAMMAGLOBULINEMIA IN MINK: SOURCES AND MODES OF INFECTION. J Infect Dis. 1964 Oct;114:341–345. doi: 10.1093/infdis/114.4.341. [DOI] [PubMed] [Google Scholar]
  11. Gorham J. R., Henson J. B., Crawford T. B., Padgett G. A. The epizootiology of aleutian disease. Front Biol. 1976;44:135–158. [PubMed] [Google Scholar]
  12. Greenfield J., Walton R., Macdonald K. R. Detection of Aleutian disease in mink: serum-plate agglutination using iodine compared with precipitation by agar-gel electrophoresis. Res Vet Sci. 1973 Nov;15(3):381–383. [PubMed] [Google Scholar]
  13. Hadlow W. J., Race R. E., Jackson T. A. Lymphoreticular proliferative disease in mink homozygous for the Aleutian gene. J Natl Cancer Inst. 1972 Nov;49(5):1455–1458. [PubMed] [Google Scholar]
  14. Henson J. B., Gorham J. R., McGuire T. C., Crawford T. B. Pathology and pathogenesis of Aleutian disease. Front Biol. 1976;44:175–205. [PubMed] [Google Scholar]
  15. Karstad L., Pridham T. J. Aleutian Disease of Mink: I. Evidence of its Viral Etiology. Can J Comp Med Vet Sci. 1962 May;26(5):97–102. [PMC free article] [PubMed] [Google Scholar]
  16. Larsen A. E., Porter D. D. Pathogenesis of aleutian disease of mink: identification of nonpersistent infections. Infect Immun. 1975 Jan;11(1):92–94. doi: 10.1128/iai.11.1.92-94.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ohshima K., Shen D. T., Henson J. B., Gorham J. R. Comparison of the lesions of Aleutian disease in mink and hypergammaglobulinemia in ferrets. Am J Vet Res. 1978 Apr;39(4):653–657. [PubMed] [Google Scholar]
  18. Padgett G. A., Reiquam C. W., Henson J. B., Gorham J. R. Comparative studies of susceptibility to infection in the Chediak-Higashi syndrome. J Pathol Bacteriol. 1968 Apr;95(2):509–522. doi: 10.1002/path.1700950224. [DOI] [PubMed] [Google Scholar]
  19. Porter D. D., Larsen A. E., Cox N. A., Porter H. G., Suffin S. C. Isolation of Aleutian disease virus of mink in cell culture. Intervirology. 1977;8(3):129–144. doi: 10.1159/000148888. [DOI] [PubMed] [Google Scholar]
  20. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J Exp Med. 1969 Sep 1;130(3):575–593. doi: 10.1084/jem.130.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. II. Enhancement of tissue lesions following the administration of a killed virus vaccine or passive antibody. J Immunol. 1972 Jul;109(1):1–7. [PubMed] [Google Scholar]
  22. Porter H. G., Porter D. D., Larsen A. E. Aleutian disease in ferrets. Infect Immun. 1982 Apr;36(1):379–386. doi: 10.1128/iai.36.1.379-386.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]

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