The majority of type 2 PA OT neurons are depolarized by adiponectin. A, Current clamp recording of a type 2 PA OT neuron in response to bath administration of 10 nm adiponectin. A majority of PA OT neurons showed a depolarizing shift in membrane potential followed by a return to baseline upon removal of adiponectin from the bath. Scale bars, 10 mV and 50 sec. B, Box and whisker summary plot of type 2 PA OT neurons and their response to adiponectin. GAD67, γ-Amino butyric acid 67; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; R1, receptor 1; R2, receptor 2; VGLUT, vesicular glutamate transporter; VP, vasopressin.