Table 1.
Physiological and biochemical parameters are shown for mice 0, 1, and 8 wk after STZ treatment
| STZ treatment (wk) | Group (n) | Body weight (g) | Systolic blood pressure (mm Hg) | Blood glucose (mg/dl) | Urine glucose (mg/dl) | Plasma insulin (ng/ml) |
|---|---|---|---|---|---|---|
| 0 | CTRL (4) | 24.9 ± 1.1 | 113 ± 10 | 81 ± 6.7 | Negative | n.d. |
| 1 | CTRL (20) | 25.5 ± 0.6 | 118 ± 7 | 76 ± 6.9 | Negative | 0.47 ± 0.10 |
| STZ (20) | 23.0 ± 0.8 | 120 ± 6 | 221 ± 25a | 0–100 | 0.08 ± 0.05a | |
| 8 | CTRL (20) | 29.4 ± 0.9 | 119 ± 9 | 95 ± 2.8 | Negative | 0.51 ± 0.2 |
| STZ (20) | 23.2 ± 1.1b | 128 ± 5 | 325 ± 28b | >1000 | 0.09 ± 0.1a |
Male BaLb/c mice were treated once with STZ (240 mg/kg, ip) or vehicle control (citrate buffer, CTRL) as described in Materials and Methods. Data are mean ± sem for n independent experiments. Statistical comparisons used two-tailed unpaired Student’s t test. n.d., Not determined.
a
P < 0.005 vs. respective CTRL values.
b
P < 0.001 vs. respective CTRL values.