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. 1983 Aug;41(2):546–548. doi: 10.1128/iai.41.2.546-548.1983

Recombinant mouse interferon-gamma regulation of antibody production.

H M Johnson, B A Torres
PMCID: PMC264676  PMID: 6409809

Abstract

Interferon-gamma produced in monkey cells by transfection with mouse interferon-gamma cDNA suppressed the mouse in vitro antibody response in a manner similar to that of natural mouse interferon-gamma. Significant suppression was obtained with as little as 1 U of interferon. Recombinant human interferon-gamma produced by cloning in a similar fashion was not suppressive. Both the suppressive and the antiviral activities of recombinant interferon-gamma were neutralized by antibodies to mouse natural interferon-gamma. Thus, interferon-gamma was responsible for the immunosuppression. At the cellular level, the recombinant interferon-gamma was capable of activating macrophages to suppress antibody production. The data provide clear-cut evidence that interferon-gamma plays an important role in regulation of immunological processes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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