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. 1983 Aug;41(2):829–833. doi: 10.1128/iai.41.2.829-833.1983

Rotavirus-associated traveler's diarrhea: neutralizing antibody in asymptomatic infections.

C C Smith, L Aurelian, M Santosham, R B Sack
PMCID: PMC264715  PMID: 6307883

Abstract

The sera of patients with traveler's diarrhea were assayed for rotavirus-specific immunoglobulins in enzyme-linked immunosorbent and micro-neutralization assays. The antigenically related simian rotavirus SA-11 was used in both assays. Although similar titers of rotavirus-specific binding immunoglobulin G and A were observed in the sera of both symptomatic and asymptomatic subjects, clinical illness appeared to correlate with the failure to detect increased (greater than or equal to fourfold) titers of neutralizing antibodies in the post- as compared with the pretravel sera.

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Selected References

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  1. Bolivar R., Conklin R. H., Vollet J. J., Pickering L. K., DuPont H. L., Walters D. L., Kohl S. Rotavirus in travelers' diarrhea: study of an adult student population in Mexico. J Infect Dis. 1978 Mar;137(3):324–327. doi: 10.1093/infdis/137.3.324. [DOI] [PubMed] [Google Scholar]
  2. Davidson G. P., Bishop R. F., Townley R. R., Holmes I. H. Importance of a new virus in acute sporadic enteritis in children. Lancet. 1975 Feb 1;1(7901):242–246. doi: 10.1016/s0140-6736(75)91140-x. [DOI] [PubMed] [Google Scholar]
  3. Echeverria P., Hodge F. A., Blacklow N. R., Vollet J. L., Cukor G., DuPont H. L., Cross J. H. Travelers' diarrhea among United States Marines in South Korea. Am J Epidemiol. 1978 Jul;108(1):68–73. [PubMed] [Google Scholar]
  4. Echeverria P., Ramirez G., Blacklow N. R., Ksiazek T., Cukor G., Cross J. H. Travelers' diarrhea among U.S. Army troops in South Korea. J Infect Dis. 1979 Feb;139(2):215–219. doi: 10.1093/infdis/139.2.215. [DOI] [PubMed] [Google Scholar]
  5. Ghose L. H., Schnagl R. D., Holmes I. H. Comparison of an enzyme-linked immunosorbent assay for quantitation of rotavirus antibodies with complement fixation in an epidemiological survey. J Clin Microbiol. 1978 Sep;8(3):268–276. doi: 10.1128/jcm.8.3.268-276.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gust I. D., Pringle R. C., Barnes G. L., Davidson G. P., Bishop R. F. Complement-fixing antibody response to rotavirus infection. J Clin Microbiol. 1977 Feb;5(2):125–130. doi: 10.1128/jcm.5.2.125-130.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kapikian A. Z., Cline W. L., Greenberg H. B., Wyatt R. G., Kalica A. R., Banks C. E., James H. D., Jr, Flores J., Chanock R. M. Antigenic characterization of human and animal rotaviruses by immune adherence hemagglutination assay (IAHA): evidence for distinctness of IAHA and neutralization antigens. Infect Immun. 1981 Aug;33(2):415–425. doi: 10.1128/iai.33.2.415-425.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kapikian A. Z., Kim H. W., Wyatt R. G., Cline W. L., Arrobio J. O., Brandt C. D., Rodriguez W. J., Sack D. A., Chanock R. M., Parrott R. H. Human reovirus-like agent as the major pathogen associated with "winter" gastroenteritis in hospitalized infants and young children. N Engl J Med. 1976 Apr 29;294(18):965–972. doi: 10.1056/NEJM197604292941801. [DOI] [PubMed] [Google Scholar]
  9. Riepenhoff-Talty M., Lee P. C., Carmody P. J., Barrett H. J., Ogra P. L. Age-dependent rotavirus-enterocyte interactions. Proc Soc Exp Biol Med. 1982 Jun;170(2):146–154. doi: 10.3181/00379727-170-41410. [DOI] [PubMed] [Google Scholar]
  10. Rodger S. M., Bishop R. F., Birch C., McLean B., Holmes I. H. Molecular epidemiology of human rotaviruses in Melbourne, Australia, from 1973 to 1979, as determined by electrophoresis of genome ribonucleic acid. J Clin Microbiol. 1981 Feb;13(2):272–278. doi: 10.1128/jcm.13.2.272-278.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ryder R. W., Oquist C. A., Greenberg H., Taylor D. N., Orskov F., Orskov I., Kapikian A. Z., Sack R. B. Travelers' diarrhea in panamanian tourists in Mexico. J Infect Dis. 1981 Nov;144(5):442–448. doi: 10.1093/infdis/144.5.442. [DOI] [PubMed] [Google Scholar]
  12. Santosham M., Sack R. B., Froehlich J., Greenberg H., Yolken R., Kapikain A., Javier C., Medina C., Orskov F., Orskov I. Biweekly prophylactic doxycycline for travelers' diarrhea. J Infect Dis. 1981 Apr;143(4):598–602. doi: 10.1093/infdis/143.4.598. [DOI] [PubMed] [Google Scholar]
  13. Sheridan J. F., Aurelian L., Barbour G., Santosham M., Sack R. B., Ryder R. W. Traveler's diarrhea associated with rotavirus infection: analysis of virus-specific immunoglobulin classes. Infect Immun. 1981 Jan;31(1):419–429. doi: 10.1128/iai.31.1.419-429.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sheridan J. F., Eydelloth R. S., Vonderfecht S. L., Aurelian L. Virus-specific immunity in neonatal and adult mouse rotavirus infection. Infect Immun. 1983 Feb;39(2):917–927. doi: 10.1128/iai.39.2.917-927.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Strnad B. C., Aurelian L. Proteins of herpesvirus type 2. III. Isolation and immunologic characterization of a large molecular weight viral protein. Virology. 1978 Jun 15;87(2):401–415. doi: 10.1016/0042-6822(78)90144-7. [DOI] [PubMed] [Google Scholar]
  16. Stuker G., Oshiro L. S., Schmidt N. J. Antigenic comparisons of two new rotaviruses from rhesus monkeys. J Clin Microbiol. 1980 Feb;11(2):202–203. doi: 10.1128/jcm.11.2.202-203.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thouless M. E., Bryden A. S., Flewett T. H., Woode G. N., Bridger J. C., Snodgrass D. R., Herring J. A. Serological relationships between rotaviruses from different species as studied by complement fixation and neutralization. Arch Virol. 1977;53(4):287–294. doi: 10.1007/BF01315627. [DOI] [PubMed] [Google Scholar]
  18. Woode G. N., Bridger J. C., Jones J. M., Flewett T. H., Davies H. A., Davis H. A., White G. B. Morphological and antigenic relationships between viruses (rotaviruses) from acute gastroenteritis of children, calves, piglets, mice, and foals. Infect Immun. 1976 Sep;14(3):804–810. doi: 10.1128/iai.14.3.804-810.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wyatt R. G., Greenberg H. B., James W. D., Pittman A. L., Kalica A. R., Flores J., Chanock R. M., Kapikian A. Z. Definition of human rotavirus serotypes by plaque reduction assay. Infect Immun. 1982 Jul;37(1):110–115. doi: 10.1128/iai.37.1.110-115.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. von Bonsdorff C. H., Hovi T., Mákelá P., Hovi T., Tevalvoto-Aarnio M. Rotavirus associated with acute gastroenteritis in adults. Lancet. 1976 Aug 21;2(7982):423–423. doi: 10.1016/s0140-6736(76)92445-4. [DOI] [PubMed] [Google Scholar]

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