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. 1983 Aug;41(2):841–843. doi: 10.1128/iai.41.2.841-843.1983

Virulence characteristics of murine cytomegalovirus in cell and organ cultures.

M C Jordan, J L Takagi
PMCID: PMC264718  PMID: 6307886

Abstract

Murine cytomegalovirus infection was studied in cell and organ cultures. Regardless of the virulence characteristics of input virus, all cultures produced attenuated murine cytomegalovirus. Virulent murine cytomegalovirus has been recovered only from salivary glands of infected mice. In vivo the maintenance of murine cytomegalovirus in a virulent state is apparently due to factors other than virus replication in epithelial cells.

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Selected References

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  1. Chong K. T., Gould J. J., Mims C. A. Neutralization of different strains of murine cytomegalovirus (MCMV)-effect of in vitro passage. Arch Virol. 1981;69(2):95–104. doi: 10.1007/BF01315153. [DOI] [PubMed] [Google Scholar]
  2. Chong K. T., Mims C. A. Murine cytomegalovirus particle types in relation to sources of virus and pathogenicity. J Gen Virol. 1981 Dec;57(Pt 2):415–419. doi: 10.1099/0022-1317-57-2-415. [DOI] [PubMed] [Google Scholar]
  3. Collier A. M., Clyde W. A., Jr, Denny F. W. Biologic effects of Mycoplasma pneumoniae and other mycoplasmas from man on hamster tracheal organ culture. Proc Soc Exp Biol Med. 1969 Dec;132(3):1153–1158. doi: 10.3181/00379727-132-34385. [DOI] [PubMed] [Google Scholar]
  4. Elek S. D., Stern H. Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero. Lancet. 1974 Jan 5;1(7845):1–5. doi: 10.1016/s0140-6736(74)92997-3. [DOI] [PubMed] [Google Scholar]
  5. Glazer J. P., Friedman H. M., Grossman R. A., Starr S. E., Barker C. F., Perloff L. J., Huang E. S., Plotkin S. A. Live cytomegalovirus vaccination of renal transplant candidates. A preliminary trial. Ann Intern Med. 1979 Nov;91(5):676–683. doi: 10.7326/0003-4819-91-5-676. [DOI] [PubMed] [Google Scholar]
  6. Henson D., Smith R. D., Gehrke J., Neapolitan C. Effect of cortisone on nonfatal mouse cytomegalovirus infection. Am J Pathol. 1967 Dec;51(6):1001–1011. [PMC free article] [PubMed] [Google Scholar]
  7. Jordan M. C. Adverse effects of cytomegalovirus vaccination in mice. J Clin Invest. 1980 Apr;65(4):798–803. doi: 10.1172/JCI109730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jordan M. C. Interstitial pneumonia and subclinical infection after intranasal inoculation of murine cytomegalovirus. Infect Immun. 1978 Jul;21(1):275–280. doi: 10.1128/iai.21.1.275-280.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jordan M. C., Mar V. L. Spontaneous activation of latent cytomegalovirus from murine spleen explants. Role of lymphocytes and macrophages in release and replication of virus. J Clin Invest. 1982 Oct;70(4):762–768. doi: 10.1172/JCI110672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jordan M. C., Takagi J. L., Stevens J. G. Activation of latent murine cytomegalovirus in vivo and in vitro: a pathogenetic role for acute infection. J Infect Dis. 1982 May;145(5):699–705. doi: 10.1093/infdis/145.2.699. [DOI] [PubMed] [Google Scholar]
  11. Nedrud J. G., Collier A. M., Pagano J. S. Cellular basis for susceptibility to mouse cytomegalovirus: evidence from tracheal organ culture. J Gen Virol. 1979 Dec;45(3):737–744. doi: 10.1099/0022-1317-45-3-737. [DOI] [PubMed] [Google Scholar]
  12. Neff B. J., Weibel R. E., Buynak E. B., McLean A. A., Hilleman M. R. Clinical and laboratory studies of live cytomegalovirus vaccine Ad-169. Proc Soc Exp Biol Med. 1979 Jan;160(1):32–37. doi: 10.3181/00379727-160-40382. [DOI] [PubMed] [Google Scholar]
  13. Osborn J. E., Medearis D. N., Jr Studies of relationship between mouse cytomegalovirus and interferon. Proc Soc Exp Biol Med. 1966 Mar;121(3):819–824. doi: 10.3181/00379727-121-30897. [DOI] [PubMed] [Google Scholar]
  14. Osborn J. E., Walker D. L. Virulence and attenuation of murine cytomegalovirus. Infect Immun. 1971 Feb;3(2):228–236. doi: 10.1128/iai.3.2.228-236.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Plotkin S. A., Farquhar J., Horberger E. Clinical trials of immunization with the Towne 125 strain of human cytomegalovirus. J Infect Dis. 1976 Nov;134(5):470–475. doi: 10.1093/infdis/134.5.470. [DOI] [PubMed] [Google Scholar]
  16. Selgrade M. K., Nedrud J. G., Collier A. M., Gardner D. E. Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus. Infect Immun. 1981 Sep;33(3):840–847. doi: 10.1128/iai.33.3.840-847.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Selgrade M. K., Osborn J. E. Role of macrophages in resistance to murine cytomegalovirus. Infect Immun. 1974 Dec;10(6):1383–1390. doi: 10.1128/iai.10.6.1383-1390.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Shanley J. D., Jordan M. C., Cook M. L., Stevens J. G. Pathogenesis of reactivated latent murine cytomegalovirus infection. Am J Pathol. 1979 Apr;95(1):67–80. [PMC free article] [PubMed] [Google Scholar]
  19. Shanley J. D., Lutwick L. I., Donta S. T. Replication of murine cytomegalovirus in murine Y-1 cells. J Med Virol. 1979;4(4):261–268. doi: 10.1002/jmv.1890040404. [DOI] [PubMed] [Google Scholar]

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