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. 1983 Jul;41(1):154–161. doi: 10.1128/iai.41.1.154-161.1983

Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes.

Y Kuroda, C J Gibbs Jr, H L Amyx, D C Gajdusek
PMCID: PMC264756  PMID: 6407995

Abstract

The mode of replication of the "unconventional virus" of Creutzfeldt-Jakob disease was studied in BALB/c mice infected intracerebrally. Virus was detected in the brain, spleen, lung, thymus, liver, kidney, and blood, but not in urine, at various time intervals after inoculation. The highest infectivity was present in the spleen from the second through the ninth weeks postinfection. Density gradient separation of spleen cells with colloidal silica (Percoll) revealed that the highest concentration of virus was present in blastoid cells from lower-density (1.05 to 1.07 g/ml) fractions. These results suggest that blastoid cells play an important role as the initial replication site of virus in the pathogenesis of Creutzfeldt-Jakob disease in mice.

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Selected References

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