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. 1983 Apr;40(1):417–420. doi: 10.1128/iai.40.1.417-420.1983

Susceptibility of congenitally athymic (nude) mice to sporotrichosis.

C L Dickerson, R L Taylor, D J Drutz
PMCID: PMC264863  PMID: 6601062

Abstract

Congenitally athymic (nu/nu) mice were found to be more susceptible to intravenous challenge with Sporothrix schenckii than their phenotypically normal (nu/+) littermates as measured by lethality and the number of viable yeast cells in the liver 7 days postinfection. Thymus reconstitution of nu/nu mice (nu/thy) conferred a significant degree of resistance to sporotrichosis. Immunization greatly enhanced the resistance of nu/thy and nu/+ mice, but unexpectedly increased the susceptibility of nu/nu mice. The susceptibility of nonimmunized nu/nu mice and the finding that thymus transplants augmented resistance to sporotrichosis suggest that T lymphocytes are critical to host defense.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson G. L., Zembala M. Contact sensitivity in the mouse. IV. The role of lymphocytes and macrophages in passive transfer and the mechanism of their interaction. J Exp Med. 1970 Jul 1;132(1):1–15. doi: 10.1084/jem.132.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaman L., Pappagianis D., Benjamini E. Significance of T cells in resistance to experimental murine coccidioidomycosis. Infect Immun. 1977 Sep;17(3):580–585. doi: 10.1128/iai.17.3.580-585.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blumenstock F. A., Saba T. M., Roccario E., Cho E., Kaplan J. E. Opsonic fibronectin after trauma and particle injection determined by a peritoneal macrophage monolayer assay. J Reticuloendothel Soc. 1981 Jul;30(1):61–71. [PubMed] [Google Scholar]
  4. Cutler J. E. Acute systemic candidiasis in normal and congenitally thymic-deficient (nude) mice. J Reticuloendothel Soc. 1976 Feb;19(2):121–124. [PubMed] [Google Scholar]
  5. Dukor P., Miller J. F., House W., Allman V. Regeneration of thymus grafts. I. Histological and cytological aspects. Transplantation. 1965 Sep;3(5):639–668. doi: 10.1097/00007890-196509000-00006. [DOI] [PubMed] [Google Scholar]
  6. Graybill J. R., Drutz D. J. Host defense in cryptococcosis. II. Cryptococcosis in the nude mouse. Cell Immunol. 1978 Oct;40(2):263–274. doi: 10.1016/0008-8749(78)90334-9. [DOI] [PubMed] [Google Scholar]
  7. Lanser M. E., Saba T. M., Scovill W. A. Opsonic glycoprotein (plasma fibronectin) levels after burn injury. Relationship to extent of burn and development of sepsis. Ann Surg. 1980 Dec;192(6):776–782. doi: 10.1097/00000658-198012000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nielsen H. S., Jr Biologic properties of skin test antigens of yeast form Sporotrichum schenckii. J Infect Dis. 1968 Apr;118(2):173–180. doi: 10.1093/infdis/118.2.173. [DOI] [PubMed] [Google Scholar]
  9. Saba T. M., Jaffe E. Plasma fibronectin (opsonic glycoprotein): its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am J Med. 1980 Apr;68(4):577–594. doi: 10.1016/0002-9343(80)90310-1. [DOI] [PubMed] [Google Scholar]
  10. Shiraishi A., Nakagaki K., Arai T. Experimental sporotrichosis in congenitally athymic (nude) mice. J Reticuloendothel Soc. 1979 Sep;26(3):333–336. [PubMed] [Google Scholar]
  11. Williams D. M., Graybill J. R., Drutz D. J. Histoplasma capsulatum infection in nude mice. Infect Immun. 1978 Sep;21(3):973–977. doi: 10.1128/iai.21.3.973-977.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]

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