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. 1983 May;40(2):486–492. doi: 10.1128/iai.40.2.486-492.1983

Immune-specific production of gamma interferon in human lymphocyte cultures in response to mumps virus.

T Nakayama
PMCID: PMC264881  PMID: 6404827

Abstract

The production of interferon (IFN) was investigated in human peripheral lymphocyte cultures stimulated by mumps virus. IFN-alpha and IFN-gamma were produced in lymphocyte cultures from immune donors. However, no IFN-gamma was produced in lymphocyte cultures from nonimmune donors. IFN-alpha was produced by B lymphocytes, and IFN-gamma was produced by T lymphocytes. An increase in the production of IFN-gamma resulted from the mixture of autologous macrophages in T-lymphocyte cultures. The production of IFN-gamma by T lymphocytes was found to depend on prior, possibly cellular, immunity.

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Selected References

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