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. 1983 May;40(2):820–824. doi: 10.1128/iai.40.2.820-824.1983

Activation of macrophages for microbicidal and tumoricidal effector functions by soluble factors from EL-4, a continuous T cell line.

C A Nacy, S L James, W R Benjamin, J J Farrar, W T Hockmeyer, M S Meltzer
PMCID: PMC264928  PMID: 6601625

Abstract

Macrophages treated with culture fluids from EL-4 cells, a continuous T cell line, were activated to kill mKSA-TU-5 fibrosarcoma cells, amastigotes of Leishmania tropica, and schistosomula of Schistosoma mansoni. Active EL-4 factors eluted from Sephadex G-100 in two distinct regions: molecular weight 45,000 (activities induced killing of unrelated intracellular and extracellular targets) and molecular weight 23,000 (activities induced killing of extracellular targets only). These results confirm heterogeneity among activation signals for the induction of macrophage microbicidal and tumoricidal activities. Factors that induced cytocidal activity against extracellular tumor cells and schistosomula were distinct from those that induced destruction of intracellular amastigotes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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