Abstract
Of the 110 consecutive isolates of Vibrio cholerae recovered from cholera patients admitted to the Infectious Diseases Hospital, Calcutta, India, between July 1989 and October 1990, 90 and 82.7% were resistant to 10 and 150 micrograms of 2,4-diamino-6,7-diisopropylpteridine (O/129), respectively. Additionally, all O/129-resistant strains of V. cholerae were multiply resistant to antimicrobial agents. Except in the cases of four strains, resistance to O/129 was invariably linked with resistance to co-trimoxazole. Although O/129 susceptibility is still a useful test for Vibrio identification, resistance of V. cholerae to this compound in local areas might occasionally pose a problem.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gerbaud G., Dodin A., Goldstein F., Courvalin P. Genetic basis of trimethoprim and O/129 resistance in Vibrio cholerae. Ann Inst Pasteur Microbiol. 1985 Nov-Dec;136B(3):265–273. doi: 10.1016/s0769-2609(85)80072-7. [DOI] [PubMed] [Google Scholar]
- Jesudason M. V., John T. J. Transferable trimethoprim resistance of Vibrio cholerae O1 encountered in southern India. Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):136–137. doi: 10.1016/0035-9203(90)90407-6. [DOI] [PubMed] [Google Scholar]
- Matsushita S., Kudoh Y., Ohashi M. Transferable resistance to the vibriostatic agent 2,4-diamino-6,7-diisopropyl-pteridine (O/129) in Vibrio cholerae. Microbiol Immunol. 1984;28(10):1159–1162. doi: 10.1111/j.1348-0421.1984.tb00773.x. [DOI] [PubMed] [Google Scholar]
- SHEWAN J. M., HODGKISS W. A method for the rapid differentiation of certain nonpathogenic, asporogenous bacilli. Nature. 1954 Jan 30;173(4396):208–209. doi: 10.1038/173208b0. [DOI] [PubMed] [Google Scholar]
- Siddique A. K., Zaman K., Majumder Y., Islam Q., Bashir I., Mutsuddy P., Eusof A. Simultaneous outbreaks of contrasting drug resistant classic and El Tor Vibrio cholerae O1 in Bangladesh. Lancet. 1989 Aug 12;2(8659):396–396. doi: 10.1016/s0140-6736(89)90579-5. [DOI] [PubMed] [Google Scholar]
- Trimethoprim resistance; epidemiology and molecular aspects. J Med Microbiol. 1990 Jan;31(1):1–19. doi: 10.1099/00222615-31-1-1. [DOI] [PubMed] [Google Scholar]