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. 2006 Oct 26;32(3-4):231–243. doi: 10.1007/s10867-006-9014-z

Optimal Length Transportation Hypothesis to Model Proteasome Product Size Distribution

Alexey Zaikin 1,✉, Juergen Kurths 1
PMCID: PMC2651524  PMID: 19669465

Abstract

This paper discusses translocation features of the 20S proteasome in order to explain typical proteasome length distributions. We assume that the protein transport depends significantly on the fragment length with some optimal length which is transported most efficiently. By means of a simple one-channel model, we show that this hypothesis can explain both the one- and the three-peak length distributions found in experiments. A possible mechanism of such translocation is provided by so-called fluctuation-driven transport.

Key words: proteasome, protein translocation, stochastic process, ratchets

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