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. 1993 Jun;31(6):1597–1600. doi: 10.1128/jcm.31.6.1597-1600.1993

Rapid detection of infectious mononucleosis-associated heterophile antibodies by a novel immunochromatographic assay and a latex agglutination test.

S E Farhat 1, S Finn 1, R Chua 1, B Smith 1, A E Simor 1, P George 1, B B Diena 1, D Diena 1, M Skulnick 1
PMCID: PMC265584  PMID: 8315001

Abstract

A novel immunochromatographic assay, the CARDS O.S. MONO test (Pacific Biotech, San Diego, Calif.), and a latex agglutination test, the Infectious Mononucleosis Kit (Unipath Ltd., Hampshire, United Kingdom) were compared with the Paul-Bunnell-Davidsohn test. Of the 957 serum specimens studied, 78 were positive and 879 were negative by the Paul-Bunnell-Davidsohn test. After discrepancies were resolved by determining Epstein-Barr virus serology, the sensitivities of the CARDS O.S. MONO test and the Infectious Mononucleosis Kit were 91.0 and 96.2%, respectively, and both tests had a specificity and a positive predictive value of 100% and a negative predictive value and overall agreement of greater than 99%. The results show that both tests can accurately detect infectious mononucleosis-associated heterophile antibodies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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