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Three candidate pathways for the synthesis of PGF2α. A cyclooxygenase (COX) enzyme produces PGH2 from arachidonic acid. PGF2α can be synthesized either directly from PGH2 via AKR1C3 or indirectly from PGE2 via AKR1C1 and AKR1C2. 11β-PGF2α can be produced from PGH2 via PGD synthase (PGDS) and AKR1C3. PGF2α is converted to inactive PGF metabolites (PGFM) via the 15-hydroxy PG dehydrogenase (PGDH). Adapted from (Watanabe, 2002).
