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. 1993 Jul;31(7):1908–1910. doi: 10.1128/jcm.31.7.1908-1910.1993

Inhibition of Acanthamoeba species by Pseudomonas aeruginosa: rationale for their selective exclusion in corneal ulcers and contact lens care systems.

M N Qureshi 1, A A Perez 2nd 1, R M Madayag 1, E J Bottone 1
PMCID: PMC265656  PMID: 8349772

Abstract

Cocultivation of Acanthamoeba castellanii and Acanthamoeba polyphaga with live Pseudomonas aeruginosa and with broth filtrates of P. aeruginosa proved equally lethal to the Acanthamoeba spp. The P. aeruginosa-induced amebicidal activity is apparently toxin mediated and has two operative modes: it can function through binding of P. aeruginosa to the ameba membrane and in the presence of one or more P. aeruginosa exoproducts.

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Selected References

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