Abstract
A new simplified chessboard system for typing of Streptococcus pneumoniae is described. It is intended for typing or grouping of 90 to 95% of the pneumococcal strains most commonly isolated from blood or cerebrospinal fluid and is based on 12 pooled diagnostic antisera, each reacting with 7 to 11 single types, together covering the 23 different vaccine-related types as well as 25 other cross-reacting types. Worldwide surveillance of the type distribution is important in order to ensure an optimal formulation of pneumococcal polysaccharide vaccines and, in the future, of polysaccharide-protein conjugate vaccines. The simplified typing system described in this paper makes it easier to carry out surveillance in other than specialized reference laboratories. Finally, it takes advantage of the fact that some types cause disease more often in children--as opposed to adults--than do others.
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Selected References
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- Austrian R., Boettger C., Dole M., Fairly L., Freid M. Streptococcus pneumoniae type 16A, a hitherto undescribed pneumococcal type. J Clin Microbiol. 1985 Jul;22(1):127–128. doi: 10.1128/jcm.22.1.127-128.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Austrian R. Pneumococcal pneumonia. Diagnostic, epidemiologic, therapeutic and prophylactic considerations. Chest. 1986 Nov;90(5):738–743. doi: 10.1378/chest.90.5.738. [DOI] [PubMed] [Google Scholar]
- Austrian R. Pneumococcal polysaccharide vaccines. Rev Infect Dis. 1989 May-Jun;11 (Suppl 3):S598–S602. doi: 10.1093/clinids/11.supplement_3.s598. [DOI] [PubMed] [Google Scholar]
- Austrian R. The quellung reaction, a neglected microbiologic technique. Mt Sinai J Med. 1976 Nov-Dec;43(6):699–709. [PubMed] [Google Scholar]
- Burman L. A., Norrby R., Trollfors B. Invasive pneumococcal infections: incidence, predisposing factors, and prognosis. Rev Infect Dis. 1985 Mar-Apr;7(2):133–142. doi: 10.1093/clinids/7.2.133. [DOI] [PubMed] [Google Scholar]
- Finland M., Barnes M. W. Changes in occurrence of capsular serotypes of Streptococcus pneumoniae at Boston City Hospital during selected years between 1935 and 1974. J Clin Microbiol. 1977 Feb;5(2):154–166. doi: 10.1128/jcm.5.2.154-166.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hager H. L., Woolley T. W., Berk S. L. Review of recent pneumococcal infections with attention to vaccine and nonvaccine serotypes. Rev Infect Dis. 1990 Mar-Apr;12(2):267–272. doi: 10.1093/clinids/12.2.267. [DOI] [PubMed] [Google Scholar]
- Henrichsen J., Robbins J. B. Production of monovalent antisera by induction of immunological tolerance for capsular typing of Streptococcus pneumoniae. FEMS Microbiol Lett. 1992 Jul 1;73(1-2):89–93. doi: 10.1016/0378-1097(92)90589-g. [DOI] [PubMed] [Google Scholar]
- Klein J. O. The epidemiology of pneumococcal disease in infants and children. Rev Infect Dis. 1981 Mar-Apr;3(2):246–253. doi: 10.1093/clinids/3.2.246. [DOI] [PubMed] [Google Scholar]
- Lund E., Rasmussen P. Omni-serum. A diagnostic Pneumococcus serum, reacting with the 82 known types of Pneumococcus. Acta Pathol Microbiol Scand. 1966;68(3):458–460. doi: 10.1111/apm.1966.68.3.458. [DOI] [PubMed] [Google Scholar]
- Nielsen S. V., Henrichsen J. Capsular types of Streptococcus pneumoniae isolated from blood and CSF during 1982-1987. Clin Infect Dis. 1992 Nov;15(5):794–798. doi: 10.1093/clind/15.5.794. [DOI] [PubMed] [Google Scholar]
- Robbins J. B., Austrian R., Lee C. J., Rastogi S. C., Schiffman G., Henrichsen J., Mäkelä P. H., Broome C. V., Facklam R. R., Tiesjema R. H. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis. 1983 Dec;148(6):1136–1159. doi: 10.1093/infdis/148.6.1136. [DOI] [PubMed] [Google Scholar]
- Shann F. Etiology of severe pneumonia in children in developing countries. Pediatr Infect Dis. 1986 Mar-Apr;5(2):247–252. doi: 10.1097/00006454-198603000-00017. [DOI] [PubMed] [Google Scholar]