Table I.
Molecules Expressed by Human Endothelial Cells Relevant for Antigen Presentation
| Category | Molecule | Comment | Rels |
|---|---|---|---|
| MHC | HLA-A,B,C | Constitutive; increased by IFN-α,β,γ TNF | (20, 21) |
| TAP1,2 | Constitutive; increased by IFN-α,β,γ TNF | (105) | |
| LMP2,7 | Constitutive; increased by IFN-α,β,γ TNF | (105) | |
| HLA-DR, DP, DQ | Basal and induced further by IFN-γ | (106) | |
| Invariant Chain | Basal and induced further by IFN-γ | (106) | |
| Costimulators | LFA-3 (CD58) | Constitutive (Ig superfamily) | (107) |
| PDL-1 | Constitutive; increased by IFN-γ (Ig superfamily) | (108) | |
| PDL-2 | Constitutive; increased by IFN-γ (Ig superfamily) | (108) | |
| ICOS-Ligand | Constitutive; increased by TNF (Ig superfamily) | (109) | |
| 4-1BB Ligand | Constitutive; increased by IFN-γ (TNF superfamily) | (7) | |
| CD40 | Constitutive; increased by IFN-γ and TNF (TNFR superfamily) | (110) | |
| Ox40-Ligand | Constitutive (TNF superfamily) | (7) | |
| GITR-Ligand | Induced by TNF (TNF superfamily) | (108) | |
| Cytokines | IL-1α | Constitutive; increased by IL-1, TNF | (111) |
| IL-6 | Induced by IL-1, TNF | (112) | |
| Other | Indolamine 2,3 dioxygenase | Induced by IFN αβγ | (113) |