Abstract
We characterized the genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients in Seattle between 1976 and 1982. By restriction endonuclease analysis, we identified three new adenovirus genomic variants, each associated with a single invasive adenovirus infection. In addition, we were able to obtain suggestive evidence for a nosocomial spread of a particular group of isolates within this population. This study demonstrates that the technique of restriction endonuclease analysis is an important epidemiological tool for investigating viral infections.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown R. S., Nogrady M. B., Spence L., Wiglesworth F. W. An outbreak of adenovirus type 7 infection in children in Montreal. Can Med Assoc J. 1973 Feb 17;108(4):434–439. [PMC free article] [PubMed] [Google Scholar]
- Brůcková M., Wadell G., Sundell G., Syrůcek L., Kunzová L. An outbreak of respiratory disease due to a type 5 adenovirus identified as genome type 5a. Acta Virol. 1980 May;24(3):161–165. [PubMed] [Google Scholar]
- Fife K. H., Ashley R., Corey L. Isolation and characterization of six new genome types of human adenovirus types 1 and 2. J Clin Microbiol. 1985 Jan;21(1):20–23. doi: 10.1128/jcm.21.1.20-23.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fife K. H., Ashley R., Shields A. F., Salter D., Meyers J. D., Corey L. Comparison of neutralization and DNA restriction enzyme methods for typing clinical isolates of human adenovirus. J Clin Microbiol. 1985 Jul;22(1):95–100. doi: 10.1128/jcm.22.1.95-100.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hirt B. Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol. 1967 Jun 14;26(2):365–369. doi: 10.1016/0022-2836(67)90307-5. [DOI] [PubMed] [Google Scholar]
- Kelsey D. S. Adenovirus meningoencephalitis. Pediatrics. 1978 Feb;61(2):291–293. [PubMed] [Google Scholar]
- Shields A. F., Hackman R. C., Fife K. H., Corey L., Meyers J. D. Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med. 1985 Feb 28;312(9):529–533. doi: 10.1056/NEJM198502283120901. [DOI] [PubMed] [Google Scholar]
- Siegel S. E., Patch C. T., Lewis A. M., Jr, Levine A. S. Simian virus 40 DNA replication, transcription, and antigen induction during infection with two adenovirus 2-SV40 hybrids that contain the entire SV40 genome. J Virol. 1975 Jul;16(1):43–52. doi: 10.1128/jvi.16.1.43-52.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stenger K., Kaffanke V., Schauerhammer G. Uber eine Adenovirus-Epidemie mit schwerer Encephalopathie. Monatsschr Kinderheilkd. 1965 Jun;113(6):438–440. [PubMed] [Google Scholar]
- Straube R. C., Thompson M. A., Van Dyke R. B., Wadell G., Connor J. D., Wingard D., Spector S. A. Adenovirus type 7b in a children's hospital. J Infect Dis. 1983 May;147(5):814–819. doi: 10.1093/infdis/147.5.814. [DOI] [PubMed] [Google Scholar]
- Wadell G., Varsányi T. M., Lord A., Sutton R. N. Epidemic outbreaks of adenovirus 7 with special reference to the pathogenicity of adenovirus genome type 7b. Am J Epidemiol. 1980 Nov;112(5):619–628. doi: 10.1093/oxfordjournals.aje.a113034. [DOI] [PubMed] [Google Scholar]
- Wadell G., de Jong J. C., Wolontis S. Molecular epidemiology of adenoviruses: alternating appearance of two different genome types of adenovirus 7 during epidemic outbreaks in Europe from 1958 to 1980. Infect Immun. 1981 Nov;34(2):368–372. doi: 10.1128/iai.34.2.368-372.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wigger H. J., Blanc W. A. Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. N Engl J Med. 1966 Oct 20;275(16):870–874. doi: 10.1056/NEJM196610202751603. [DOI] [PubMed] [Google Scholar]