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. 2008 Nov 5;113(13):3017–3026. doi: 10.1182/blood-2008-06-163121

Figure 6.

Figure 6

NK1R and CD40 signaling act synergistically to promote BMDC survival. (A) Bar-diagram representing the percentage of CD11c+ BMDCs expressing Bcl-2 after culture in medium alone or with SarSP for different time points. Agonistic CD40 mAb was added at 24 hours to cultures, and the percentage of CD11c+ BMDCs expressing Bcl-2 was analyzed at each time point. *P < .05, **P < .01, and ***P < .001. Means (± SD) of 3 independent experiments are shown. (B) Contour-plots illustrating the presence of SarSP-TN-DCs or TN-DCs (CD11c+CFSE+) in DLNs 5d after adoptive transference of DCs in B6 mice treated with or without the CD154 (CD40L) neutralizing MR1 mAb. Data are representative of 3 independent experiments.