Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1988 Mar;26(3):429–432. doi: 10.1128/jcm.26.3.429-432.1988

Risk factors for candidemia in cancer patients: a case-control study.

A Karabinis 1, C Hill 1, B Leclercq 1, C Tancrède 1, D Baume 1, A Andremont 1
PMCID: PMC266307  PMID: 3356785

Abstract

Risk factors for candidemia were analyzed in a case-control study of 30 cancer patients with candidemia and 58 controls. In a univariate analysis, previous surgery, neutropenia, central catheterization, chemotherapy, specific antibiotic treatments, and peripheral cultures positive for Candida spp. were associated with a significantly increased risk of candidemia. In a multivariate logistic model, the significant risk factors for candidemia were positive peripheral cultures for Candida spp. (P = 0.02), central catheterization (P = 0.03), and neutropenia (P = 0.05). These results should help to identify cancer patients with a high risk of candidemia, who should be given early systemic antifungal therapy.

Full text

PDF
429

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernard E. M., Wong B., Armstrong D. Stereoisomeric configuration of arabinitol in serum, urine, and tissues in invasive candidiasis. J Infect Dis. 1985 Apr;151(4):711–715. doi: 10.1093/infdis/151.4.711. [DOI] [PubMed] [Google Scholar]
  2. Bodey G. P. Candidiasis in cancer patients. Am J Med. 1984 Oct 30;77(4D):13–19. [PubMed] [Google Scholar]
  3. DeGregorio M. W., Lee W. M., Linker C. A., Jacobs R. A., Ries C. A. Fungal infections in patients with acute leukemia. Am J Med. 1982 Oct;73(4):543–548. doi: 10.1016/0002-9343(82)90334-5. [DOI] [PubMed] [Google Scholar]
  4. Dyess D. L., Garrison R. N., Fry D. E. Candida sepsis. Implications of polymicrobial blood-borne infection. Arch Surg. 1985 Mar;120(3):345–348. doi: 10.1001/archsurg.1985.01390270083014. [DOI] [PubMed] [Google Scholar]
  5. Greenfield R. A., Bussey M. J., Stephens J. L., Jones J. M. Serial enzyme-linked immunosorbent assays for antibody to Candida antigens during induction chemotherapy for acute leukemia. J Infect Dis. 1983 Aug;148(2):275–283. doi: 10.1093/infdis/148.2.275. [DOI] [PubMed] [Google Scholar]
  6. Horn R., Wong B., Kiehn T. E., Armstrong D. Fungemia in a cancer hospital: changing frequency, earlier onset, and results of therapy. Rev Infect Dis. 1985 Sep-Oct;7(5):646–655. doi: 10.1093/clinids/7.5.646. [DOI] [PubMed] [Google Scholar]
  7. Maki D. G., Weise C. E., Sarafin H. W. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med. 1977 Jun 9;296(23):1305–1309. doi: 10.1056/NEJM197706092962301. [DOI] [PubMed] [Google Scholar]
  8. Maksymiuk A. W., Thongprasert S., Hopfer R., Luna M., Fainstein V., Bodey G. P. Systemic candidiasis in cancer patients. Am J Med. 1984 Oct 30;77(4D):20–27. [PubMed] [Google Scholar]
  9. Meunier-Carpentier F., Kiehn T. E., Armstrong D. Fungemia in the immunocompromised host. Changing patterns, antigenemia, high mortality. Am J Med. 1981 Sep;71(3):363–370. doi: 10.1016/0002-9343(81)90162-5. [DOI] [PubMed] [Google Scholar]
  10. Myerowitz R. L., Pazin G. J., Allen C. M. Disseminated candidiasis. Changes in incidence, underlying diseases, and pathology. Am J Clin Pathol. 1977 Jul;68(1):29–38. doi: 10.1093/ajcp/68.1.29. [DOI] [PubMed] [Google Scholar]
  11. Pizzo P. A., Robichaud K. J., Gill F. A., Witebsky F. G. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med. 1982 Jan;72(1):101–111. doi: 10.1016/0002-9343(82)90594-0. [DOI] [PubMed] [Google Scholar]
  12. Sandford G. R., Merz W. G., Wingard J. R., Charache P., Saral R. The value of fungal surveillance cultures as predictors of systemic fungal infections. J Infect Dis. 1980 Oct;142(4):503–509. doi: 10.1093/infdis/142.4.503. [DOI] [PubMed] [Google Scholar]
  13. Schwartz R. S., Mackintosh F. R., Schrier S. L., Greenberg P. L. Multivariate analysis of factors associated with invasive fungal disease during remission induction therapy for acute myelogenous leukemia. Cancer. 1984 Feb 1;53(3):411–419. doi: 10.1002/1097-0142(19840201)53:3<411::aid-cncr2820530308>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  14. Washington J. A., 2nd, Ilstrup D. M. Blood cultures: issues and controversies. Rev Infect Dis. 1986 Sep-Oct;8(5):792–802. doi: 10.1093/clinids/8.5.792. [DOI] [PubMed] [Google Scholar]
  15. Weinstein M. P., Reller L. B., Mirrett S., Wang W. L., Alcid D. V. Clinical comparison of an agar slide blood culture bottle with tryptic soy broth and a conventional blood culture bottle with supplemented peptone broth. J Clin Microbiol. 1985 May;21(5):815–818. doi: 10.1128/jcm.21.5.815-818.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. de Repentigny L., Reiss E. Current trends in immunodiagnosis of candidiasis and aspergillosis. Rev Infect Dis. 1984 May-Jun;6(3):301–312. doi: 10.1093/clinids/6.3.301. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES