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FGF2 and EP4 regulate the expression of A. RANKL, B. OPG, and C. CTSK mRNAs associated with bone resorption in lumbar vertebral bodies from ovariectomized (OVX) rats. Figures present fold changes relative to r18s from of the following experimental groups: Baseline OVX (BSL OVX), and OVX rats treated for 3 weeks with FGF2 (OVX+FGF2) or EP4 (OVX+EP4). Values are the mean ± SD from 5 OVX rats per group. aSignificantly different from BSL OVX (P<0.05).
