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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1988 May;26(5):1031–1033. doi: 10.1128/jcm.26.5.1031-1033.1988

Alterations in the T-lymphocyte subpopulation in patients with rhinoscleroma.

P Berron 1, R Berron 1, L Ortiz-Ortiz 1
PMCID: PMC266511  PMID: 2968362

Abstract

T-lymphocyte subpopulations were studied in a group of patients with rhinoscleroma due to Klebsiella rhinoscleromatis. The data demonstrated that these patients had a significantly greater number of T-suppressor/cytotoxic lymphocytes than did clinically healthy individuals. This finding correlated with a diminished response to the T-cell mitogen concanavalin A. The evidence indicated that the T-cell response of these patients was decreased and may reflect the host's response to the bacterial invader, thus explaining the chronicity of the disease.

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Selected References

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  1. Bloom B. R., Mehra V. Immunological unresponsiveness in leprosy. Immunol Rev. 1984 Aug;80:5–28. doi: 10.1111/j.1600-065x.1984.tb00493.x. [DOI] [PubMed] [Google Scholar]
  2. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
  3. Castellanos-Barba C., Islas-Rodríguez A., Morales R., González-Mendoza A., Zambrano-Villa S., Ortiz-Ortiz L. Lepromatous leprosy: study of some subpopulations of lymphocytes and their functional analysis. Arch Invest Med (Mex) 1985 Apr-Jun;16(2):217–224. [PubMed] [Google Scholar]
  4. Griswold D. E., Badger A. M., Bender P. E., Sitrin R. D., Antell L., Greig R. G., Poste G. Differential effects of intact subunits and nicked fragments of concanavalin A on immune functions in vitro and in vivo. J Immunol. 1983 Oct;131(4):1626–1628. [PubMed] [Google Scholar]
  5. Hoffmann E. O., Loose L. D., Harkin J. C. The Mikulicz cell in rhinoscleroma. Light, fluorescent and electron microscopic studies. Am J Pathol. 1973 Oct;73(1):47–58. [PMC free article] [PubMed] [Google Scholar]
  6. Islas-Rodriguez A. E., Morales-Ortiz R., Fafutis-Morris M., González-Mendoza A., Ortiz-Ortiz L. Deficiency in the biosynthesis of interleukin 2 (IL-2) and functional presence of the IL-2 receptor in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1987 Sep;55(3):566–569. [PubMed] [Google Scholar]
  7. Kaplan M. E., Clark C. An improved rosetting assay for detection of human T lymphocytes. J Immunol Methods. 1974 Jul;5(2):131–135. doi: 10.1016/0022-1759(74)90003-9. [DOI] [PubMed] [Google Scholar]
  8. Mackaness G. B., Blanden R. V. Cellular immunity. Prog Allergy. 1967;11:89–140. [PubMed] [Google Scholar]
  9. Meyer P. R., Shum T. K., Becker T. S., Taylor C. R. Scleroma (Rhinoscleroma). A histologic immunohistochemical study with bacteriologic correlates. Arch Pathol Lab Med. 1983 Jul;107(7):377–383. [PubMed] [Google Scholar]
  10. Modlin R. L., Hofman F. M., Meyer P. R., Sharma O. P., Taylor C. R., Rea T. H. In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis. Clin Exp Immunol. 1983 Mar;51(3):430–438. [PMC free article] [PubMed] [Google Scholar]
  11. North M. E., Newton C. A., Wright D. J., Webster A. D. Bactericidal activity of serum for Klebsiella rhinoscleromatis: studies on serum from a patient with rhinoscleroma and sera deficient in antibody or complement. J Med Microbiol. 1982 May;15(2):267–272. doi: 10.1099/00222615-15-2-267. [DOI] [PubMed] [Google Scholar]
  12. O'Neill G. J., Parrott D. M. Locomotion of human lymphoid cells. I. Effect of culture and con A on T and non-T lymphocytes. Cell Immunol. 1977 Oct;33(2):257–267. doi: 10.1016/0008-8749(77)90156-3. [DOI] [PubMed] [Google Scholar]
  13. Ortiz-Ortiz L., Weigle W. O. Activation of effector cells in experimental allergic encephalomyelitis by interleukin 2 (IL-2). J Immunol. 1982 Apr;128(4):1545–1550. [PubMed] [Google Scholar]
  14. Reinherz E. L., Schlossman S. F. Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med. 1980 Aug 14;303(7):370–373. doi: 10.1056/NEJM198008143030704. [DOI] [PubMed] [Google Scholar]
  15. Ridley M. J., Ridley D. S., Turk J. L. Surface markers on lymphocytes and cells of the mononuclear phagocyte series in skin sections in leprosy. J Pathol. 1978 Jun;125(2):91–98. doi: 10.1002/path.1711250204. [DOI] [PubMed] [Google Scholar]
  16. Rojas-Espinosa O., Estrada-Parra S. Inmunochemistry of the Capsular polysaccharide of Klebsiella rhinoscleromatis. Rev Latinoam Microbiol Parasitol (Mex) 1968 Jan-Mar;10(1):7–10. [PubMed] [Google Scholar]
  17. Stiernberg C. M., Clark W. D. Rhinoscleroma--a diagnostic challenge. Laryngoscope. 1983 Jul;93(7):866–870. doi: 10.1288/00005537-198307000-00003. [DOI] [PubMed] [Google Scholar]
  18. Strickland N. H. The influence of immunosuppression and immunodeficiency on infections with leprosy and tuberculosis. Int J Lepr Other Mycobact Dis. 1985 Mar;53(1):86–100. [PubMed] [Google Scholar]
  19. Talaat M., Soliman A., Gaafar H., Belal A., Jr Experimental scleroma. A histopathological study. J Laryngol Otol. 1978 Jun;92(6):489–498. doi: 10.1017/s0022215100085650. [DOI] [PubMed] [Google Scholar]
  20. Toppozada H., Elsawy M., Malaty R., Dogheim Y. The skin window test in rhinoscleroma contacts. J Laryngol Otol. 1984 May;98(5):475–479. doi: 10.1017/s0022215100146924. [DOI] [PubMed] [Google Scholar]
  21. Toppozada H., Mazloum H., El-Sawy M., Malaty R., Yakout Y. The complement fixation test in rhinoscleroma. J Laryngol Otol. 1983 Jan;97(1):55–57. doi: 10.1017/s0022215100093804. [DOI] [PubMed] [Google Scholar]

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