Abstract
T-lymphocyte subpopulations were studied in a group of patients with rhinoscleroma due to Klebsiella rhinoscleromatis. The data demonstrated that these patients had a significantly greater number of T-suppressor/cytotoxic lymphocytes than did clinically healthy individuals. This finding correlated with a diminished response to the T-cell mitogen concanavalin A. The evidence indicated that the T-cell response of these patients was decreased and may reflect the host's response to the bacterial invader, thus explaining the chronicity of the disease.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bloom B. R., Mehra V. Immunological unresponsiveness in leprosy. Immunol Rev. 1984 Aug;80:5–28. doi: 10.1111/j.1600-065x.1984.tb00493.x. [DOI] [PubMed] [Google Scholar]
- Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
- Castellanos-Barba C., Islas-Rodríguez A., Morales R., González-Mendoza A., Zambrano-Villa S., Ortiz-Ortiz L. Lepromatous leprosy: study of some subpopulations of lymphocytes and their functional analysis. Arch Invest Med (Mex) 1985 Apr-Jun;16(2):217–224. [PubMed] [Google Scholar]
- Griswold D. E., Badger A. M., Bender P. E., Sitrin R. D., Antell L., Greig R. G., Poste G. Differential effects of intact subunits and nicked fragments of concanavalin A on immune functions in vitro and in vivo. J Immunol. 1983 Oct;131(4):1626–1628. [PubMed] [Google Scholar]
- Hoffmann E. O., Loose L. D., Harkin J. C. The Mikulicz cell in rhinoscleroma. Light, fluorescent and electron microscopic studies. Am J Pathol. 1973 Oct;73(1):47–58. [PMC free article] [PubMed] [Google Scholar]
- Islas-Rodriguez A. E., Morales-Ortiz R., Fafutis-Morris M., González-Mendoza A., Ortiz-Ortiz L. Deficiency in the biosynthesis of interleukin 2 (IL-2) and functional presence of the IL-2 receptor in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1987 Sep;55(3):566–569. [PubMed] [Google Scholar]
- Kaplan M. E., Clark C. An improved rosetting assay for detection of human T lymphocytes. J Immunol Methods. 1974 Jul;5(2):131–135. doi: 10.1016/0022-1759(74)90003-9. [DOI] [PubMed] [Google Scholar]
- Mackaness G. B., Blanden R. V. Cellular immunity. Prog Allergy. 1967;11:89–140. [PubMed] [Google Scholar]
- Meyer P. R., Shum T. K., Becker T. S., Taylor C. R. Scleroma (Rhinoscleroma). A histologic immunohistochemical study with bacteriologic correlates. Arch Pathol Lab Med. 1983 Jul;107(7):377–383. [PubMed] [Google Scholar]
- Modlin R. L., Hofman F. M., Meyer P. R., Sharma O. P., Taylor C. R., Rea T. H. In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis. Clin Exp Immunol. 1983 Mar;51(3):430–438. [PMC free article] [PubMed] [Google Scholar]
- North M. E., Newton C. A., Wright D. J., Webster A. D. Bactericidal activity of serum for Klebsiella rhinoscleromatis: studies on serum from a patient with rhinoscleroma and sera deficient in antibody or complement. J Med Microbiol. 1982 May;15(2):267–272. doi: 10.1099/00222615-15-2-267. [DOI] [PubMed] [Google Scholar]
- O'Neill G. J., Parrott D. M. Locomotion of human lymphoid cells. I. Effect of culture and con A on T and non-T lymphocytes. Cell Immunol. 1977 Oct;33(2):257–267. doi: 10.1016/0008-8749(77)90156-3. [DOI] [PubMed] [Google Scholar]
- Ortiz-Ortiz L., Weigle W. O. Activation of effector cells in experimental allergic encephalomyelitis by interleukin 2 (IL-2). J Immunol. 1982 Apr;128(4):1545–1550. [PubMed] [Google Scholar]
- Reinherz E. L., Schlossman S. F. Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med. 1980 Aug 14;303(7):370–373. doi: 10.1056/NEJM198008143030704. [DOI] [PubMed] [Google Scholar]
- Ridley M. J., Ridley D. S., Turk J. L. Surface markers on lymphocytes and cells of the mononuclear phagocyte series in skin sections in leprosy. J Pathol. 1978 Jun;125(2):91–98. doi: 10.1002/path.1711250204. [DOI] [PubMed] [Google Scholar]
- Rojas-Espinosa O., Estrada-Parra S. Inmunochemistry of the Capsular polysaccharide of Klebsiella rhinoscleromatis. Rev Latinoam Microbiol Parasitol (Mex) 1968 Jan-Mar;10(1):7–10. [PubMed] [Google Scholar]
- Stiernberg C. M., Clark W. D. Rhinoscleroma--a diagnostic challenge. Laryngoscope. 1983 Jul;93(7):866–870. doi: 10.1288/00005537-198307000-00003. [DOI] [PubMed] [Google Scholar]
- Strickland N. H. The influence of immunosuppression and immunodeficiency on infections with leprosy and tuberculosis. Int J Lepr Other Mycobact Dis. 1985 Mar;53(1):86–100. [PubMed] [Google Scholar]
- Talaat M., Soliman A., Gaafar H., Belal A., Jr Experimental scleroma. A histopathological study. J Laryngol Otol. 1978 Jun;92(6):489–498. doi: 10.1017/s0022215100085650. [DOI] [PubMed] [Google Scholar]
- Toppozada H., Elsawy M., Malaty R., Dogheim Y. The skin window test in rhinoscleroma contacts. J Laryngol Otol. 1984 May;98(5):475–479. doi: 10.1017/s0022215100146924. [DOI] [PubMed] [Google Scholar]
- Toppozada H., Mazloum H., El-Sawy M., Malaty R., Yakout Y. The complement fixation test in rhinoscleroma. J Laryngol Otol. 1983 Jan;97(1):55–57. doi: 10.1017/s0022215100093804. [DOI] [PubMed] [Google Scholar]