Abstract
Campylobacter pylori was isolated from the gastric mucosa in 6 of 24 pigtailed macaques (Macaca nemestrina) examined by gastric biopsy and culture; 3 isolates were recovered during gastroendoscopy, and 3 were recovered at necropsy. The isolates were morphologically and biochemically similar to the human type strain NCTC 11638, differing only in colony diameter, pigmentation, and rate of growth. Identity of the isolates was confirmed by whole-genomic DNA-DNA hybridization with the type strain. Colonization of the monkey stomachs was associated with hypochlorhydria and histologic features resembling type B chronic gastritis in humans. Host animals exhibited no morbid clinical effects of colonization, although endoscopy revealed inflammation, erythema, and friable tissue in some animals. The discovery of C. pylori occurring spontaneously in M. nemestrina extends the known range of the hosts of the organism and offers the possibility of a natural or experimental model of the infection in monkeys.
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- Borromeo M., Lambert J. R., Pinkard K. J. Evaluation of "CLO-test" to detect Campylobacter pyloridis in gastric mucosa. J Clin Pathol. 1987 Apr;40(4):462–463. doi: 10.1136/jcp.40.4.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Curry A., Jones D. M., Eldridge J. Spiral organisms in the baboon stomach. Lancet. 1987 Sep 12;2(8559):634–635. doi: 10.1016/s0140-6736(87)93032-7. [DOI] [PubMed] [Google Scholar]
- Dooley C. P., Cohen H. The clinical significance of Campylobacter pylori. Ann Intern Med. 1988 Jan;108(1):70–79. doi: 10.7326/0003-4819-108-1-70. [DOI] [PubMed] [Google Scholar]
- Fox J. G., Edrise B. M., Cabot E. B., Beaucage C., Murphy J. C., Prostak K. S. Campylobacter-like organisms isolated from gastric mucosa of ferrets. Am J Vet Res. 1986 Feb;47(2):236–239. [PubMed] [Google Scholar]
- Hamilton B. E., Natelson B. H. Ultradian rhythms of gastric acidity. Pavlov J Biol Sci. 1984 Jan-Mar;19(1):32–35. doi: 10.1007/BF03003104. [DOI] [PubMed] [Google Scholar]
- Hartmann D., von Graevenitz A. A note on name, viability and urease tests of Campylobacter pylori. Eur J Clin Microbiol. 1987 Feb;6(1):82–83. doi: 10.1007/BF02097207. [DOI] [PubMed] [Google Scholar]
- Harvey S. M. Hippurate hydrolysis by Campylobacter fetus. J Clin Microbiol. 1980 Apr;11(4):435–437. doi: 10.1128/jcm.11.4.435-437.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hazell S. L., Borody T. J., Gal A., Lee A. Campylobacter pyloridis gastritis I: Detection of urease as a marker of bacterial colonization and gastritis. Am J Gastroenterol. 1987 Apr;82(4):292–296. [PubMed] [Google Scholar]
- Hazell S. L., Lee A. Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers. Lancet. 1986 Jul 5;2(8497):15–17. doi: 10.1016/s0140-6736(86)92561-4. [DOI] [PubMed] [Google Scholar]
- Marshall B. J., Warren J. R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984 Jun 16;1(8390):1311–1315. doi: 10.1016/s0140-6736(84)91816-6. [DOI] [PubMed] [Google Scholar]
- Newell D. G., Hudson M. J., Baskerville A. Naturally occurring gastritis associated with Campylobacter pylori infection in the rhesus monkey. Lancet. 1987 Dec 5;2(8571):1338–1338. doi: 10.1016/s0140-6736(87)91236-0. [DOI] [PubMed] [Google Scholar]
- Perera D. R., Weinstein W. M., Rubin C. E. Symposium on pathology of the gastrointestinal tract-Part II. Small intestinal biopsy. Hum Pathol. 1975 Mar;6(2):157–217. doi: 10.1016/s0046-8177(75)80176-6. [DOI] [PubMed] [Google Scholar]
- Sato T., Takeuchi A. Infection by spirilla in the stomach of the rhesus monkey. Vet Pathol Suppl. 1982 Sep;7:17–25. [PubMed] [Google Scholar]