Skip to main content
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1988 Sep;26(9):1783–1786. doi: 10.1128/jcm.26.9.1783-1786.1988

Incidence of enteric adenoviruses among children in Thailand and the significance of these viruses in gastroenteritis.

J E Herrmann 1, N R Blacklow 1, D M Perron-Henry 1, E Clements 1, D N Taylor 1, P Echeverria 1
PMCID: PMC266716  PMID: 2846648

Abstract

In countries with temperate climates, enteric adenoviruses have been shown to be a substantial cause of pediatric gastroenteritis. To determine the incidence of adenovirus infection in a tropical climate, stools were collected from children under age 7 during a 1-year period at an outpatient clinic in Bangkok, Thailand. Stools from 1,114 children with gastroenteritis and from 947 children without gastroenteritis were tested. Each stool was tested for adenovirus group antigen and for specific enteric adenovirus types (Ad40 and Ad41) by monoclonal antibody enzyme immunoassays. We found that 4.4% (49 of 1,114) of children with gastroenteritis and 1.8% (17 of 947) of children without gastroenteritis were positive for adenovirus group antigen. In tests for specific enteric adenovirus types, 2.0% (22 of 1,114) of the tests were positive in children with gastroenteritis and 0.6% (6 of 947) were positive in children without gastroenteritis. There was a significant correlation (P less than 0.02) of gastroenteritis with nonenteric adenovirus types (27 of 1,114) as well as with specific enteric adenovirus types (P less than 0.01). By comparison, 19.7% of children with gastroenteritis and 0.7% of those without gastroenteritis were positive for rotavirus infection. In the adenovirus-infected children with gastroenteritis, there were coinfections with rotavirus only in those with nonenteric adenovirus infection (7 of 27 children). There were no significant differences in the association of bacterial or parasitic infections with either enteric or nonenteric adenovirus infections in either group of children studied. These data demonstrate that Ad40 and Ad41 are causes of gastroenteritis in this population, but among the spectrum of diarrheal etiologies, they may be proportionately less important than they are in countries with temperate climates.

Full text

PDF
1783

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brandt C. D., Kim H. W., Rodriguez W. J., Arrobio J. O., Jeffries B. C., Stallings E. P., Lewis C., Miles A. J., Chanock R. M., Kapikian A. Z. Pediatric viral gastroenteritis during eight years of study. J Clin Microbiol. 1983 Jul;18(1):71–78. doi: 10.1128/jcm.18.1.71-78.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brandt C. D., Kim H. W., Rodriguez W. J., Arrobio J. O., Jeffries B. C., Stallings E. P., Lewis C., Miles A. J., Gardner M. K., Parrott R. H. Adenoviruses and pediatric gastroenteritis. J Infect Dis. 1985 Mar;151(3):437–443. doi: 10.1093/infdis/151.3.437. [DOI] [PubMed] [Google Scholar]
  3. Brandt C. D., Rodriguez W. J., Kim H. W., Arrobio J. O., Jeffries B. C., Parrott R. H. Rapid presumptive recognition of diarrhea-associated adenoviruses. J Clin Microbiol. 1984 Nov;20(5):1008–1009. doi: 10.1128/jcm.20.5.1008-1009.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cepko C. L., Whetstone C. A., Sharp P. A. Adenovirus hexon monoclonal antibody that is group specific and potentially useful as a diagnostic reagent. J Clin Microbiol. 1983 Feb;17(2):360–364. doi: 10.1128/jcm.17.2.360-364.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cevenini R., Mazzaracchio R., Rumpianesi F., Donati M., Moroni A., Sambri V., La Placa M. Prevalence of enteric adenovirus from acute gastroenteritis: a five year study. Eur J Epidemiol. 1987 Jun;3(2):147–150. doi: 10.1007/BF00239751. [DOI] [PubMed] [Google Scholar]
  6. Cukor G., Perron D. M., Hudson R., Blacklow N. R. Detection of rotavirus in human stools by using monoclonal antibody. J Clin Microbiol. 1984 Jun;19(6):888–892. doi: 10.1128/jcm.19.6.888-892.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gary G. W., Jr, Hierholzer J. C., Black R. E. Characteristics of noncultivable adenoviruses associated with diarrhea in infants: a new subgroup of human adenoviruses. J Clin Microbiol. 1979 Jul;10(1):96–103. doi: 10.1128/jcm.10.1.96-103.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Herrmann J. E., Blacklow N. R., Perron D. M., Cukor G., Krause P. J., Hyams J. S., Barrett H. J., Ogra P. L. Enzyme immunoassay with monoclonal antibodies for the detection of rotavirus in stool specimens. J Infect Dis. 1985 Oct;152(4):830–832. doi: 10.1093/infdis/152.4.830. [DOI] [PubMed] [Google Scholar]
  9. Herrmann J. E., Perron-Henry D. M., Blacklow N. R. Antigen detection with monoclonal antibodies for the diagnosis of adenovirus gastroenteritis. J Infect Dis. 1987 Jun;155(6):1167–1171. doi: 10.1093/infdis/155.6.1167. [DOI] [PubMed] [Google Scholar]
  10. Herrmann J. E., Perron-Henry D. M., Stobbs-Walro D., Blacklow N. R. Preparation and characterization of monoclonal antibodies to enteric adenovirus types 40 and 41. Arch Virol. 1987;94(3-4):259–265. doi: 10.1007/BF01310718. [DOI] [PubMed] [Google Scholar]
  11. Leite J. P., Pereira H. G., Azeredo R. S., Schatzmayr H. G. Adenoviruses in faeces of children with acute gastroenteritis in Rio de Janeiro, Brazil. J Med Virol. 1985 Feb;15(2):203–209. doi: 10.1002/jmv.1890150213. [DOI] [PubMed] [Google Scholar]
  12. Madeley C. R. The emerging role of adenoviruses as inducers of gastroenteritis. Pediatr Infect Dis. 1986 Jan-Feb;5(1 Suppl):S63–S74. doi: 10.1097/00006454-198601001-00012. [DOI] [PubMed] [Google Scholar]
  13. Oishi I., Yamazaki K., Minekawa Y., Nishimura H., Kitaura T. Three-year survey of the epidemiology of rotavirus, enteric adenovirus, and some small spherical viruses including "Osaka-agent" associated with infantile diarrhea. Biken J. 1985 Jun;28(1-2):9–19. [PubMed] [Google Scholar]
  14. Taylor D. N., Echeverria P., Pál T., Sethabutr O., Saiborisuth S., Sricharmorn S., Rowe B., Cross J. The role of Shigella spp., enteroinvasive Escherichia coli, and other enteropathogens as causes of childhood dysentery in Thailand. J Infect Dis. 1986 Jun;153(6):1132–1138. doi: 10.1093/infdis/153.6.1132. [DOI] [PubMed] [Google Scholar]
  15. Uhnoo I., Wadell G., Svensson L., Johansson M. E. Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children. J Clin Microbiol. 1984 Sep;20(3):365–372. doi: 10.1128/jcm.20.3.365-372.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Uhnoo I., Wadell G., Svensson L., Johansson M. Two new serotypes of enteric adenovirus causing infantile diarrhoea. Dev Biol Stand. 1983;53:311–318. [PubMed] [Google Scholar]
  17. de Jong J. C., Wigand R., Kidd A. H., Wadell G., Kapsenberg J. G., Muzerie C. J., Wermenbol A. G., Firtzlaff R. G. Candidate adenoviruses 40 and 41: fastidious adenoviruses from human infant stool. J Med Virol. 1983;11(3):215–231. doi: 10.1002/jmv.1890110305. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES